放射性核素功能显像在原发性醛固酮增多症中的研究进展  

Radionuclide functional imaging in primary aldosteronism: An update

作　　者：曹登敏 林美福[1] 陈刚[2] Cao Dengmin;Lin Meifu;Chen Gang(Department of Nuclear Medicine,Fujian Provincial Hospital,Fuzhou 350000,China;Department of Endocrinology,Fujian Provincial Hospital,Fuzhou 350000,China)

机构地区：[1]福建省立医院核医学科,福州350000 [2]福建省立医院内分泌科,福州350000

出　　处：《中华内分泌代谢杂志》2021年第11期1025-1028,共4页Chinese Journal of Endocrinology and Metabolism

摘　　要：原发性醛固酮增多症(primary aldosteronism,PA)是常见的继发性高血压病因,区分单、双侧肾上腺病变在PA治疗方案选择中至关重要。虽然肾上腺静脉采血(AVS)已被指南推荐为"金标准",但存在侵入性、技术难度大等局限性。无创功能显像成为一种选择。11C-MTO、123I-IMTO以及68Ga-pentixafor与传统碘胆固醇显像剂相比,具有较高的特异性,在缩短获取图像时间、减少对患者的辐射暴露和提高图像分辨率方面更具优势。但这些新型的功能显像剂在识别直径小于1 cm腺瘤的灵敏度方面存在局限性,有待进一步研究。本文将对放射性核素功能显像在PA诊断中的研究及进展作详细评述。Primary aldosteronism(PA)is a common cause of secondary hypertension.Differentiation of unilateral from bilateral lesions is essential in the treatment options of PA.Although adrenal vein blood sample(AVS)has been recommended as a"gold standard"by the guidelines,there are limitations such as invasive and technical difficulty.Noninvasive functional imaging is an option.Compared with traditional iodine cholesterol imaging,11C-MTO,123I-IMTO,and 68Ga-pentixafor have higher specificity and more advantages in shortening the acquisition time,reducing radiation exposure to patients and improving image resolution.However,these new functional imaging agents still have limitations in identifying the sensitivity of adenomas less than 1 cm,which need further study.This article reviews the research progress of radionuclide functional imaging in PA diagnosis.

关 键 词：原发性醛固酮增多症 诊断 功能显像 PET/CT 

分 类 号：R586.24[医药卫生—内分泌]