慢性阻塞性肺疾病急性加重期呼吸衰竭患者应用急诊无创正压通气治疗的效果观察  

Observation on the effect of emergency noninvasive positive pressure ventilation in patients with acute exacerbation of chronic obstructive pulmonary disease and respiratory failure

作　　者：曹鸽 孟艳[1] 卢宁[1] CAO Ge;MENG Yan;LU Ning(Emergency Department,Huludao Central Hospital,Huludao 125000,China)

机构地区：[1]葫芦岛市中心医院急诊科,125000

出　　处：《中国现代药物应用》2021年第22期34-37,共4页Chinese Journal of Modern Drug Application

摘　　要：目的 探究急诊无创正压通气(NPPV)在慢性阻塞性肺疾病急性加重期(AECOPD)呼吸衰竭患者中的应用效果。方法 74例AECOPD呼吸衰竭患者,以随机信封法分为参照组及研究组,各37例。两组均接受基础治疗,在此基础上参照组采用常规吸氧治疗,研究组采用急诊NPPV治疗。对比两组患者血气指标、临床疗效、气管插管率及死亡率。结果 治疗72 h,研究组动脉血氧分压(PaO_(2))(75.23±7.24)mm Hg(1 mm Hg=0.133 kPa)、pH(7.40±0.02)高于参照组的(60.58±6.17)mm Hg、(7.38±0.02),动脉血二氧化碳分压(PaCO_(2))(39.12±3.06)mm Hg低于参照组的(44.24±3.85)mm Hg,差异有统计学意义(P<0.05)。研究组总有效率94.59%高于参照组的78.38%,差异有统计学意义(P<0.05)。研究组气管插管率5.41%、死亡率0均低于参照组的21.62%、10.81%,差异有统计学意义(P<0.05)。结论 急诊NPPV更有助于改善AECOPD呼吸衰竭患者血气指标,提升临床治疗效果,并有助于降低气管插管率、死亡率。Objective To investigate the application effect of emergency noninvasive positive pressure ventilation(NPPV)in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)and respiratory failure.Methods A total of 74 patients with AECOPD and respiratory failure were divided into the reference group and the research group by random envelope method,with 37 cases in each group.Both groups received basic treatment.On this basis,the reference group was treated with conventional oxygen therapy,and the research group was treated with emergency NPPV.The blood gas indicators,clinical efficacy,tracheal intubation rate and mortality rate were compared between the two groups.Results After 72 h of treatment,the arterial partial pressure of oxygen(PaO_(2))(75.23±7.24)mm Hg(1 mm Hg=0.133 kPa)and pH(7.40±0.02)in the research group were higher than(60.58±6.17)mm Hg and(7.38±0.02)in the reference group,and the arterial partial pressure of carbon dioxide(PaCO_(2))(39.12±3.06)mm Hg was lower than(44.24±3.85)mm Hg in the reference group.All the differences were statistically significant(P<0.05).The total effective rate 94.59%of the research group was higher than 78.38%of the reference group,and the difference was statistically significant(P<0.05).The tracheal intubation rate 5.41%and mortality rate 0 of the research group were lower than 21.62%and 10.81%of the reference group,and the difference was statistically significant(P<0.05).Conclusion Emergency NPPV is more helpful to improve the blood gas indicators of AECOPD patients with respiratory failure,enhance the clinical effect,and help reduce the tracheal intubation rate and mortality rate.

关 键 词：急诊 无创正压通气 慢性阻塞性肺疾病急性加重期 呼吸衰竭 

分 类 号：R563.9[医药卫生—呼吸系统] R563.8[医药卫生—内科学]