地奈德乳膏联合除湿止痒软膏治疗小儿慢性湿疹的疗效及对其不良反应分析  

Efficacy of Desonide Cream Combined with Dehumidification and Antipruritic Ointment in the Treatment of Children with Chronic Eczema and Analysis of Its Adverse Reactions

作　　者：盛建梅 SHENG Jianmei(Department of Dermatology,Maternal and Child Health Hospital of Danyang City,Danyang,Jiangsu Province,212300 China)

机构地区：[1]江苏省丹阳市妇幼保健院皮肤科,江苏丹阳212300

出　　处：《世界复合医学》2021年第10期171-174,共4页World Journal of Complex Medicine

摘　　要：目的探讨对小儿慢性湿疹采用地奈德乳膏联合除湿止痒软膏治疗的临床疗效以及不良反应情况。方法选取该院2020年1—12月诊治的慢性湿疹患儿110例,按照随机数表法分为两组,每组各55例。两组均常规口服地氯雷他定干混悬剂,对照组单外用地奈德乳膏治疗,研究组采用地奈德联合除湿止痒软膏治疗,两组均于疗程结束后比较治疗效果,于治疗前后对浸润肥厚、抓痕、苔藓化、红斑体征进行评分,分析患儿体征改善情况,统计两组患儿治疗期间不良反应的发生情况进行用药安全性的分析,并随访5个月分析患儿复发情况。结果研究组慢性湿疹治疗总有效率为96.36%,高于对照组的81.82%;随访期间复发率为0.00%,低于对照组的10.91%,差异有统计学意义(χ^(2)=5.986、4.407,P<0.05)。治疗后,研究组浸润肥厚、抓痕、苔藓化、红斑症状评分分别为(1.25±0.31)分、(1.05±0.41)分、(0.81±0.37)分、(1.21±0.46)分,均小于对照组,差异有统计学意义(t=9.188、7.581、9.293、4.967,P<0.05)。研究组治疗期间不良反应发生率为3.64%,低于对照组的14.55%,差异有统计学意义(χ^(2)=3.962,P<0.05)。结论对小儿慢性湿疹在外用地奈德乳膏的基础上联用除湿止痒软膏治疗可提高临床疗效,有利于改善患儿体征,且用药安全可靠,疗效巩固。Objective To investigate the clinical efficacy and adverse effects of denide cream combined with dehumidification and anti-itching ointment in pediatric chronic eczema.Methods selected the hospital from January to December 2020 to diagnose and treat 110 children with chronic eczema,and divided them into two groups of 55 cases in accordance with the random number table method.Both groups received routine oral desloratadine dry suspension,the control group was treated with desonide cream alone,and the study group was treated with desonide combined with dehumidification and antipruritic ointment.The two groups compared the treatment effect after the treatment,and scored the signs of infiltration,hypertrophy,scratching,lichenification,and erythema before and after the treatment.Analyzed the improvement of the children's physical signs,count the occurrence of adverse reactions during the treatment of the two groups of children,analyzed the safety of medication,and follow up for 5 months to analyze the recurrence of the children.Results The total effective rate of treatment of chronic eczema in the study group was 96.36%,which was higher than 81.82%in the control group;the recurrence rate during follow-up was 0.00%,which was lower than 10.91%in the control group.The difference was statistically significant(χ^(2)=5.986,4.407,P<0.05).After treatment,the scores of infiltration,hypertrophy,scratching,lichenification,and erythema in the study group were(1.25±0.31)points,(1.05±0.41)points,(0.81±0.37)points,and(1.21±0.46)points,respectively,which were lower than those of the control group,the difference was statistically significant(t=9.188,7.581,9.293,4.967,P<0.05).The incidence of adverse reactions during the treatment period in the study group was 3.64%,which was lower than that in the control group,14.55%,the difference was statistically significant(χ^(2)=3.962,P<0.05).Conclusion The treatment of anti-itching ointment on the basis of chronic eczema can improve the clinical effect,improve the signs,be safe and reliab

关 键 词：小儿慢性湿疹 地奈德乳膏 除湿止痒软膏 不良反应 症状评分 

分 类 号：R751[医药卫生—皮肤病学与性病学]