血清糖类抗原125在慢性房颤并发HFpEF诊断和预后评估中的意义  

Significance of serum carbohydrate antigen 125 in diagnosis and prognosis of chronic atrial fibrillation complicated with HFpEF

作　　者：崔泽岩[1] 刘晓娟[1] 刘树理[1] 臧艳静 孙倩[2] 赵卫东[3] CUI Zeyan;LIU Xiaojuan;LIU Shuli;ZANG Yanjing;SUN Qian;ZHAO Weidong(Department of Geriatrics,Baoding Second Hospital,Baoding,Hebei 071000,China;Department of Cardiology,Baoding Second Hospital,Baoding,Hebei 071000,China;Department of Special Needs Clinic,Baoding Second Hospital,Baoding,Hebei 071000,China)

机构地区：[1]保定市第二医院老年病科,河北省保定市071000 [2]保定市第二医院心内科,河北省保定市071000 [3]保定市第二医院特需诊疗科,河北省保定市071000

出　　处：《中南医学科学杂志》2021年第6期687-690,共4页Medical Science Journal of Central South China

基　　金：保定市科技计划项目(1941ZF005)。

摘　　要：目的探究血清糖类抗原125(CA125)水平在慢性房颤并发射血分数保留性心力衰竭(HFpEF)诊断和预后评估中的临床意义。方法选取慢性房颤患者200例,其中100例合并HFpEF(HFpEF组),100例无HFpEF(慢性房颤组)。比较两组血清CA125、N末端脑钠肽前体(NT-proBNP)水平,评价血清CA125和NT-proBNP诊断慢性房颤并发HFpEF以及预测其预后的价值。结果HFpEF组血清CA125、NT-proBNP水平均明显高于慢性房颤组(P<0.05)。血清CA125、NT-proBNP联合诊断慢性房颤并发HFpEF的曲线下面积(AUC)为0.885,大于二者单独诊断,联合诊断的最佳灵敏度、特异度分别为77.02%、91.05%。血清CA125、NT-proBNP联合预测HFpEF慢性房颤预后不良的AUC为0.836,大于二者单独预测,联合预测的最佳灵敏度、特异度分别为70.09%、78.85%。结论HFpEF慢性房颤患者血清CA125水平明显升高,其与血清NT-proBNP联合检测在慢性房颤患者并发HFpEF诊断及预后预测方面具有较高临床应用价值。Aim To explore the value of serum carbohydrate antigen 125(CA125)level in the diagnosis and prognosis of chronic atrial fibrillation and heart failure with preserved ejection fraction(HFpEF).Methods 200 patients with chronic atrial fibrillation in our hospital were selected,100 of which were patients with HFpEF and chronic atrial fibrillation,as the study group,and the other 100 patients with chronic atrial fibrillation without heart failure,as the control group.Compare the general data,serum CA125 and N-terminal pro-brain natriuretic peptide(NT-proBNP)levels between the two groups,evaluate the value of serum CA125 and NT-proBNP in diagnosing chronic atrial fibrillation patients with HFpEF,and predict the prognosis value of HFpEF in chronic atrial fibrillation patients.Results The serum CA125 and NT proBNP levels in HFpEF group were significantly higher than those in chronic atrial fibrillation group(P<0.05).The area under the curve(AUC)of serum CA125 and NT proBNP in the combined diagnosis of chronic atrial fibrillation complicated with HFpEF was 0.885,which was greater than that of the two alone.The best sensitivity and specificity of the combined diagnosis were 77.02%and 91.05%respectively.The AUC of serum CA125 and NT proBNP in predicting the poor prognosis of HFpEF chronic atrial fibrillation was 0.836,which was greater than that predicted by them alone.The best sensitivity and specificity of combined prediction were 70.09%and 78.85%respectively.Conclusions The level of serum CA125 in patients with HFpEF and chronic atrial fibrillation increased significantly.Its combination with serum NT proBNP has high clinical value in the diagnosis and prognosis of patients with chronic atrial fibrillation complicated with HFpEF.

关 键 词：慢性房颤 糖类抗原125 射血分数保留性心力衰竭 N末端脑钠肽前体 

分 类 号：R541.75[医药卫生—心血管疾病]