纤维介素蛋白2在HBV感染孕妇中的表达及临床意义研究  

Expression of FGL2 in pregnant women with HBV infectionand its clinical significance

作　　者：黄慧慧[1] 陈武玲 朱焕金[1] 鞠爱萍[1] Huang Huihui;Chen Wuling;Zhu Huanjin;Ju Aiping(Department of clinical laboratory,maternal and child health hospital(Huzhong hospital),Huadu district,Guangzhou,Guangdong,510800,China)

机构地区：[1]广州市花都区妇幼保健院(胡忠医院)检验科,广东广州510800

出　　处：《齐齐哈尔医学院学报》2021年第22期1955-1958,共4页Journal of Qiqihar Medical University

基　　金：广州市花都区科信局(19-HDWS-084)。

摘　　要：目的探讨纤维介素蛋白2(FGL2)在乙型肝炎病毒(HBV)感染孕妇中的表达及临床意义。方法选择2020年7—9月本院收治的HBV感染孕妇80名作为观察组;另选择同期入住本院的无HBV感染孕妇80例作为对照组。所有HBV感染孕妇均口服富马酸替诺福韦酯二吡夫酯片抗病毒治疗,从孕24周开始每日口服300 mg/次,每日1次,持续服用至分娩结束后1个月。采集受试者空腹外周静脉血5 ml,收集血清,采用酶联免疫吸附法测定血清FGL2水平;采用速率法测定丙氨酸转氨酶(ALT)和天冬氨酸转氨酶(AST)水平,采用重氮法测定总胆红素(TBIL)水平。比较两组血清FGL2水平变化,血清ALT、AST和TBIL水平变化;治疗前后血清FGL2水平变化,血清ALT、AST和TBIL水平变化;采用Pearson分析FGL2与ALT、AST和TBIL相关性;采用ROC曲线分析血清FGL2对HBV感染孕妇诊断价值。结果观察组血清FGL2水平高于对照组(P<0.05)。观察组血清ALT、AST和TBIL水平高于对照组(P<0.05)。治疗后血清FGL2水平低于治疗前(P<0.05)。治疗后血清ALT、AST和TBIL水平低于治疗前(P<0.05)。血清FGL2与ALT、AST和TBIL呈线性相关性(P<0.05)。经ROC曲线分析,FGL2对HBV感染孕妇诊断灵敏度为88.68%,特异度为62.96%。结论FGL2在HBV感染孕妇中表达水平明显升高,具有良好诊断灵敏度和特异度,可作为评价HBV感染孕妇诊断和治疗的有效指标,具有重要临床研究价值。Objective To investigate the expression and clinical significance of fibrinogen-like protein 2(FGL2)in pregnant women with hepatitis B virus(HBV)infection.Methods The 80 pregnant women with HBV infection admitted to this hospital from July to September 2020 were selected as the observation group,another 80 pregnant women without HBV infection who were admitted to the hospital during the same period were selected as the control group.All pregnant women with HBV infection received oral administration of tenofovir disoproxil fumarate tablets for antiviral treatment,starting from 24 weeks of pregnancy,orally 300 mg once a day,once a day,and continuing to take them until 1 month after the end of childbirth.Collect 5ml of fasting peripheral venous blood from the objects to isolate serum,and measure serum FGL2 level by enzyme-linked immunosorbent assay;the rate method was used to determine the levels of alanine aminotransferase(ALT)and aspartate aminotransferase(AST),and the diazo method was used to determine the total bilirubin(TBIL)level.The changes in serum FGL2 levels,serum ALT,AST and TBIL levels were compared between the two groups;the changes in serum FGL2 levels before and after treatment,and the changes in serum ALT,AST and TBIL levels were compared.Pearson analysis was used to analyze the correlation between FGL2 and ALT,AST and TBIL.The ROC curve was used to analyze the diagnostic value of serum FGL2 in pregnant women with HBV infection.Results The level of serum FGL2 in the observation group was higher than the control group(P<0.05).The levels of ALT,AST and TBIL in the observation group were higher than the control group(P<0.05).The level of serum FGL2 after treatment was lower than that before treatment(P<0.05).After treatment,the levels of ALT,AST and TBIL were lower than those before treatment(P<0.05).There was a linear correlation between serum FGL2 and ALT,AST and TBIL(P<0.05).ROC curve analysis showed that the sensitivity and specificity of FGL2 in the diagnosis of pregnant women with HBV infection we

关 键 词：纤维介素蛋白2 乙型肝炎病毒 感染孕妇 

分 类 号：R512.6[医药卫生—内科学]