血清bFGF、IL-32水平与骨髓增生异常综合征患者预后的相关性  

Correlation between serum levels of b FGF and IL-32 and prognosis of patients with myelodysplastic syndrome

作　　者：芮明忠 芦茜 RUI Mingzhong;LU Qian(Department of Hematology,Shangrao Municipal Hospital,Shangrao,Jiangxi,334000,China)

机构地区：[1]上饶市立医院血液内科,江西上饶334000

出　　处：《当代医学》2021年第35期95-97,共3页Contemporary Medicine

摘　　要：目的分析血清碱性成纤维细胞生长因子(b FGF)、白细胞介素-32(IL-32)水平与骨髓增生异常综合征(MDS)患者预后的相关性。方法回顾性分析2014年10月至2020年1月本院收治的50例MDS患者的临床资料,检测患者血清bFGF、IL-32水平,根据预后状况分为预后不良组(n=13)与预后良好组(n=37),分析血清bFGF、IL-32水平与MDS患者预后的相关性。结果50例MDS患者中预后不良13例,发生率为26.00%;预后不良组血清b FGF、IL-32水平高于预后良好组,差异有统计学意义(P<0.05);绘制受试者工作特征曲线(ROC),血清bFGF、IL-32水平单独及联合预测MDS患者预后不良的曲线下面积(AUC)均>0.7,均有一定的预测价值,且联合检测效果最佳。结论血清bFGF、IL-32水平与MDS患者预后存在相关性,即血清bFGF、IL-32水平升高可能会增加MDS患者预后不良风险,临床可通过检测血清bFGF、IL-32水平预测MDS患者预后情况,对未来干预及改善患者预后具有一定积极意义。Objective To analyze the correlation between serum basic fibroblast growth factor(bFGF)and interleukin-32(IL-32)levels and the prognosis of patients with myelodysplastic syndrome(MDS).Methods The clinical data of 50 patients with MDS admitted to our hospital from October 2014 to November 2020 were retrospectively analyzed,serum levels of bFGF and IL-32 of patients were measured,they were divide into poor prognosis group(n=13)and good prognosis group(n=37)according to the prognosis status,the correlation between serum levels of bFGF and IL-32 and prognosis of MDS patients were analyzed.Results Among the 50 cases of MDS patients,13 cases had poor prognosis,the incidence was26.00%;the serum levels of bFGF and IL-32 in the poor prognosis group were higher than the good prognosis group,the difference was statistically significant(P<0.05);receiver operating characteristic curve(ROC)was drawn,the area under the curve(AUC)of serum bFGF and IL-32 levels alone or in combination predicted poor prognosis of MDS patients were>0.7,all of them had certain predictive value,and the effect of combined detection was the best.Conclusion Serum levels of b FGF and IL-32 are correlated with the prognosis of MDS patients,namely the increase of serum bFGF and IL-32 levels may increase the risk of poor prognosis in MDS patients,serum bFGF and IL-32 levels can be used to predict the prognosis of MDS patients in clinic,which may have positive significance for the future intervention and the improvement of patients’prognosis.

关 键 词：骨髓增生异常综合征 血清碱性成纤维细胞生长因子 白细胞介素 预后 

分 类 号：R551.3[医药卫生—血液循环系统疾病]