ERASE:a novel nucleic-acid based antiviral mechanism  

作　　者：George Fu Gao 

机构地区：[1]CAS Key Laboratory of Pathogen Microbiology and Immunology,Institute of Microbiology,Chinese Academy of Sciences,Beijing,China [2]Chinese Center for Disease Control and Prevention,Beijing,China

出　　处：《Cell Research》2021年第11期1142-1143,共2页细胞研究（英文版）

摘　　要：Nucleic acid-based antiviral systems,including CRISPR/Cas and RNA interference,play important roles in antiviral defense.In a paper recently published in Cell Research,Wu et al.revealed a novel nucleic acid-based antiviral mechanism against RNA viruses in mouse embryonic stem cells,which relies on the endogenous reverse transcriptase to produce viral complementary DNA and then RNase H1 to destroy the viral RNA.In nature,life has evolved different types of antiviral immune mechanisms to combat viral infection,which can be divided into two major categories:the protein-based antiviral mechanism and the nucleic acid-based antiviral mechanism.

关 键 词：CRISPR/Cas mechanism. al. 

分 类 号：R392[医药卫生—免疫学]