凝血酶敏感蛋白-1与多囊卵巢综合征血管生成的研究进展  

Research Progress of Thrombospondin-1 and Polycystic Ovary Syndrome Angiogenesis

作　　者：张婷[1] 王超[1] 张玉红[1] 王芳芳[1] 刘羽[1] 刘宁 田婷婷 刘梅梅[1] ZHANG Ting;WANG Chao;ZHANG Yuhong;WANG Fangfang;LIU Yu;LIU Ning;TIAN Tingting;LIU Meimei(Department of Gynecology and Obstetrics,the Second Affiliated Hospital of Harbin Medical University,Harbin 150081,China)

机构地区：[1]哈尔滨医科大学附属第二医院妇产科,哈尔滨150081

出　　处：《医学综述》2021年第23期4702-4707,共6页Medical Recapitulate

基　　金：黑龙江省自然科学基金(LH2019H070);哈尔滨医科大学附属第二医院中青年创新科学研究基金(KYCX2018-03)。

摘　　要：多囊卵巢综合征(PCOS)是最常见的妇科内分泌疾病,严重影响女性的生殖健康。PCOS的病理生理机制目前尚未明确,因此对于PCOS的治疗仍存在争议。PCOS患者常出现卵巢血流改变和血管生成异常,而这些改变可能与PCOS患者排卵率降低、激素异常以及卵巢多囊样改变相关。作为一种抗血管生成因子,凝血酶敏感蛋白-1(TSP-1)在PCOS患者血清中低表达,且与PCOS卵巢血管异常生成有关。因此,以TSP-1为治疗靶点,恢复卵巢正常的血管生成可改善PCOS患者的卵泡发育和排卵率,为PCOS的治疗提供新思路。Polycystic ovary syndrome(PCOS)is the most common gynecologic endocrine disease,which seriously affects the reproductive health of women.The pathophysiological mechanism of PCOS is currently unclear,so the treatment of PCOS is still controversial.PCOS patients often have changes in ovarian blood flow and abnormal angiogenesis,which may be related to decreased ovulation rate,hormone abnormalities and polycystic ovarian changes in the patients.As an anti-angiogenic factor,thrombospondin-1(TSP-1)is low in the serum of PCOS patients and it is related to abnormal ovarian angiogenesis in PCOS.Therefore,with TSP-1 as a therapeutic target,restoring the normal angiogenesis in the ovary can improve follicular development and ovulation rate in the PCOS patients,and provide new ideas for the treatment of PCOS.

关 键 词：多囊卵巢综合征 凝血酶敏感蛋白-1 血管生成 无排卵性不孕症 

分 类 号：R711.75[医药卫生—妇产科学]