核桃青皮正丁醇部位化学成分的研究  

Chemical constituents from the n-butanol fraction of the green walnut husks of Juglans mandshurica

作　　者：周媛媛[1] 刘宁雨 马丹娜 高蕙蕊 于海龙[2] 刘艳[1] ZHOU Yuan-yuan;LIU Ning-yu;MA Dan-na;GAO Hui-rui;YU Hai-long;LIU Yan(College of Pharmacy,Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,China;Harbin Food and Drug Inspection and Testing Center,Harbin 150525,China)

机构地区：[1]黑龙江中医药大学药学院,黑龙江哈尔滨150040 [2]哈尔滨市食品药品检验检测中心,黑龙江哈尔滨150525

出　　处：《中成药》2021年第12期3373-3377,共5页Chinese Traditional Patent Medicine

基　　金：国家自然基金项目(81202890);黑龙江省自然科学基金项目(LH2019H048);中国博士后特别资助项目(2014T70374);中国博士后面上资助项目(一等)(2013M530164);黑龙江省博士后科研启动金资助项目(LBH-Q16207)。

摘　　要：目的研究核桃Juglans mandshurica Maxim青皮正丁醇部位的化学成分。方法核桃青皮甲醇提取物采用硅胶、ODS进行分离纯化,根据理化性质及波谱数据鉴定所得化合物的结构。结果从中分离得到15个化合物,分别鉴定为1,4,8-三羟基萘-1-O-β-D-[6″-O-(4″-羟基-3″,5″-二甲氧基苯甲酰)]-葡萄糖苷(1)、1,4,8-三羟基-3-萘甲酸-1-O-β-D-葡萄糖苷甲酯(2)、1,4,8-三羟基萘-1-O-β-D-葡糖醛基-(1→6)-α-L-阿拉伯糖苷(3)、4,5,8-三羟基-α-四氢萘醌-5-O-β-D-[6′-O-(4″-羟基-3″,5″-二甲氧基苯甲酰基)]-葡萄糖苷(4)、4′-羟基异黄酮-7-O-β-D-半乳糖苷(5)、山柰酚-3-O-α-L-鼠李糖苷(6)、槲皮素-7-O-β-D-吡喃葡萄糖苷(7)、山柰酚-7-O-β-D-吡喃葡萄糖苷(8)、槲皮素-3-O-(2″-没食子酰基)-鼠李糖苷(9)、木犀草素-7-O-β-D-葡糖醛酸乙酯(10)、木犀草苷(11)、4′,5,7-三羟基-3′,6,8-三甲氧基黄酮(12)、短叶松素(13)、苦参醇W(14)。结论化合物1~5、7~11、13为首次从该植物中分离得到,化合物5、9为首次从胡桃属中分离得到。AIM To study the chemical constituents from the n-butanol fraction of green walnut husks of Juglans mandshurica Maxim.METHODS The methanol extract from the green walnut husk of J.mandshurica was isolated and purified by silica and ODS,then the structures of obtained compounds were identified by physicochemical properties and spectral data.RESULTS Fourteen compounds were isolated and identified as 1,4,8-trihydroxy naphthalene-1-O-β-D-[6″-O-(4″-hydroxy-3″,5″-dimethyoxy benzoyl)]-glucopyranoside(1),1,4,8-trihydroxy-3-naphthalene carboxylic acid-1-O-β-D-glucopyranoside methyl ester(2),1,4,8-trihydroxy naphthalene-1-O-β-D-glucopyranosyl-(1→6)-α-L-arabinopyranoside(3),4,5,8-trihydroxy-α-tetralone-5-O-β-D-[6′-O-(4″-hydroxy-3″,5″-dimethoxybenzoyl)]glucopyranoside(4),4′-hydroxyisoflavone-7-O-β-D-galactoside(5),kaempferol-3-O-α-L-rhamnoside(6),quercetin-7-O-β-D-glucopyranoside(7),kaempferol-7-O-β-D-glucopy ranoside(8),quercetin-3-rhamnoside-2″-gallate(9),luteolin-7-O-β-D-glucuronide ethyl ester(10),luteoloside(11),4′,5,7-trihydroxy-3′,6,8-trimethoxyflavonoid(12),pinobanksin(13),kushenol W(14).CONCLUSION Compounds 1-5,7-11,13 are isolated from this plant for the first time,and compounds 5,9 are first isolated from genus Juglans.

关 键 词：核桃青皮 正丁醇部位 化学成分 分离鉴定 

分 类 号：R284.1[医药卫生—中药学]