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作 者:兰岚 袁佳佳 周恒 苗水 李雯婷 季申 LAN Lan;YUAN Jia-jia;ZHOU Heng;MIAO Shui;LI Wen-ting;JI Shen(NMPA Key Laboratory for Quality Control of Traditional Chinese Medicine,Shanghai Institute for Food and Drug Control,Shanghai 201203,China)
机构地区:[1]上海市食品药品检验研究院,国家药品监督管理局中药质量控制重点实验室,上海201203
出 处:《中成药》2021年第12期3392-3396,共5页Chinese Traditional Patent Medicine
基 金:国家重点研发计划(2017YFC1700800);上海市自然科学基金(20ZR1450700);上海市科技人才计划项目(17YF1417100)。
摘 要:目的建立QuEChERS/UPLC-MS/MS法测定中药材中代森锰锌和丙森锌残留。方法采用QuEChERS前处理结合甲基化衍生的方法,分散固相萃取净化后通过超高效液相色谱-串联质谱测定,利用空白基质匹配的标准曲线内标法定量。结果在优化的前处理方法下,代森锰锌、丙森锌在0.005~1.0 mg/L范围内线性关系良好(r>0.9900),代森锰锌加样回收率78.3%~99.6%,丙森锌加样回收率75.2%~100.4%,RSD均小于10%。结论该方法可用于中药材中代森锰锌和丙森锌的快速、灵敏和专属测定。AIM To establish a QuEChERS/UPLC-MS/MS method for determination of mancozeb and propineb residues in Chinese medicinal plants.METHODS Residual analysis of mancozeb and propineb was performed by the combinative use of QuEChERS and iodomethane methylation.UPLC-MS/MS was performed following the purification by dispersive solid-phase extraction.The quantitative analysis was achieved by matrix-matched calibration solution with internal standard.RESULTS Under optimized conditions,mancozeb and propineb shared satisfying linearities within the range of 0.005-1.0 mg/L(r>0.9900);and accuracies of 78.3%-99.6%and 75.2%-100.4%respectively in four spiked levels with less than 10%RSDs.CONCLUSION This rapid and sensitive method can be specifically applied in the determination of mancozeb and propineb residues in Chinese medicinal plants.
关 键 词:中药材 代森锰锌 丙森锌 甲基化 QuEChERS/UPLC-MS/MS
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