血清淀粉样蛋白A联合白细胞介素-6在小儿肺炎支原体肺炎中的应用价值  

Values of Serum Amyloid A Combined with Interleukin-6 in Children with Mycoplasma Pneumoniae Pneumonia

作　　者：左路广 刘振奎[1] 刘建华[1] 卢艳辉[1] 黄冠杰 李晓蕊 Zuo Luguang;Liu Zhenkui;Liu Jianhua(Department of Laboratory,Pediatric Internal Medicine,Respiratory and Critical Care Medicine,and Reproductive Medicine,The First Affiliated Hospital of Hebei North University,Zhangjiakou,Hebei 075000,China)

机构地区：[1]河北北方学院附属第一医院检验科,儿内科,呼吸与危重症医学科,生殖医学科,河北张家口075000 [2]唐山中心医院检验科,河北唐山063000

出　　处：《四川医学》2021年第11期1082-1086,共5页Sichuan Medical Journal

基　　金：河北省医学科学研究课题计划(编号:20211499)。

摘　　要：目的研究血清淀粉样蛋白A(SAA)联合白细胞介素-6(IL-6)在小儿肺炎支原体肺炎(MPP)早期筛查、病程监控及愈后判断中的价值。方法回顾性分析2019年1月至2020年12月住院治疗的120例肺炎支原体肺炎患儿(MPP组)病例,并选取同期健康体检儿童(健康组)、细菌性肺炎(细菌组)、病毒性肺炎(病毒组)患儿作对照,比较各组SAA、IL-6水平差异,研究SAA、IL-6水平在肺炎支原体肺炎患儿病程中的变化以及轻、重症患儿中的差异,将SAA、IL-6纳入受试者工作特征曲线(ROC),计算曲线下面积(AUC)、敏感度及特异性等指标。结果MPP组SAA水平与其他各组含量比较,高于健康组低于病毒组、细菌组,差异有统计学意义(P<0.05),IL-6水平高于健康组、病毒组低于细菌组,差异有统计学意义(P<0.05);SAA、IL-6含量随MPP病程总体趋于下降,轻症患儿SAA、IL-6水平与重症患儿比较,差异均有统计学意义(P<0.05);SAA联合IL-6诊断早期小儿肺炎支原体肺炎性能较好,AUC为0.93(95%CI 0.90~0.97),SAA联合IL-6筛查小儿肺炎支原体肺炎敏感度为85.0%,特异度为89.0%。结论SAA联合IL-6可作为小儿肺炎支原体肺炎早期筛查、病程监控及愈后判断的参考。Objective To study the value of serum amyloid A(SAA)combined with interleukin-6(IL-6)in early screening,monitoring disease course and prognosis of mycoplasma pneumoniae pneumonia(MPP)in children.Methods From January 2019 to December 2020,120 cases of MPP children(MPP group)hospitalized were retrospectively analyzed.Healthy children(health group),bacterial pneumonia children(bacterial group)and viral pneumonia children(viral group)were selected during the same period as control groups.SAA and IL-6 in each group were compared.Changes of SAA and IL-6 in disease course and differences between mild and severe cases were studied.SAA and IL-6 were included in receiver operating characteristic curve(ROC)that the area under the curve(AUC),sensitivity and specificity were calculated.Results Compared with other groups,SAA in MPP group was higher than that in health group and lower than that in virus group and bacteria group(P<0.05),IL-6 in MPP group was higher than that in health group and lower than that in virus group and bacteria group(P<0.05).SAA and IL-6 decreased with MPP course,and there were significant differences between mild and severe cases(P<0.05).SAA combined with IL-6 had better performance to diagnose early children MPP that AUC was 0.93(95%CI 0.90~0.97),sensitivity and specificity in screening children MPP were 85.0%and 89.0%,respectively.Conclusion SAA combined with IL-6 could be used as a reference for early screening,monitoring disease course and prognosis of MPP in children.

关 键 词：血清淀粉样蛋白A 白细胞介素-6 肺炎支原体肺炎 小儿 感染标志物 

分 类 号：R725.6[医药卫生—儿科]