灯心草的化学成分、药理活性及临床应用研究进展  

Research progress on chemical constituents,pharmacological activities and clinical application of Juncus effusus

作　　者：张宝 马晓[1] 唐娟 杨红 陈婷婷 田洪星 陈思颖 李勇军[3] 李悦[1] ZHANG Bao;MA Xiao;TANG Juan;YANG Hong;CHEN Ting-ting;TIAN Hong-xing;CHEN Si-ying;LI Yong-jun;LI Yue(Department of Pharmacy,Guiyang Maternal and Child Healthcare Hospital,Guiyang 550003,China;Guizhou Key Laboratory of Pharmaceutics,Guizhou Medical University,Guiyang 550004,China;Engineering Research Center for Development and Application of Ethnic Medicine,TCM(Ministry of Education)&State Key Laboratory of Functions and Applications of Medicinal Plants,Guizhou Medical University,Guiyang 550004,China;Center for Drug Inspection of Guizhou Medical Products Administration,Guiyang 550081,China)

机构地区：[1]贵阳市妇幼保健院药学部,贵州贵阳550003 [2]贵州医科大学贵州省药物制剂重点实验室,贵州贵阳550004 [3]贵州医科大学民族药与中药开发应用教育部工程研究中心/省部共建药用植功效与利用国家重点实验室,贵州贵阳550004 [4]贵州省药品监督管理局检查中心,贵州贵阳550081

出　　处：《中草药》2021年第21期6701-6716,共16页Chinese Traditional and Herbal Drugs

基　　金：贵州省科技计划项目(20162820)。

摘　　要：灯心草Juncus effusus是灯心草科灯心草属植物,以其干燥茎髓或全草入药,在我国有着悠久的药用历史,灯心草主要含有9,10-二氢菲类、菲类、菲类二聚体类、芘类、甘油酯类、黄酮类、三萜类及甾体类等成分,具有镇静、抗癌、抗炎、抑菌、抗氧化、抑藻等生物活性,临床上常用于各类炎症、带状疱疹、甲状腺功能亢进及胃肠道症状的治疗。通过文献检索,对近40年来国内外相关文献进行归类、分析和总结,综述了灯心草的化学成分、药理活性及临床应用的研究进展,旨在为其进一步研究和开发利用提供参考。Juncus effusus,a kind of Juncus plant of Juncaceae family,with a long medication history in China,its dry stem or whole-plant have been used as medicine.It mainly contains 9,10-dihydrophenanthrenes,phenanthrenes,phenanthrene dimer,pyrenes,glycerides,flavonoids,triterpenes and steroids,which have a wide range of pharmacological activities,such as sedation,anti-cancer,anti-inflammatory,anti-bacterial,anti-oxidation,antialgal activities,and etc.In clinical practice,J.effusus is often used in treatment of various inflammation,herpes zoster,hyperthyroidism and gastrointestinal symptoms.Through literature search,the relevant literatures of J.effusus at home and abroad in recent 40 years were classified,analyzed and summarized.Chemical constituents,pharmacological activities and clinical application of J.effusus were reviewed in this paper,which will provide references for further research,development and utilization of this plant.

关 键 词：灯心草 9 10-二氢菲类 菲类 菲类二聚体 镇静 抗癌 带状疱疹 

分 类 号：R282.710.5[医药卫生—中药学]