糖皮质激素联合甲巯咪唑治疗甲亢的效果及对患者血清FT_(4)、FT_(3)水平的影响探讨  

Effect of glucocorticoid combined with methimazole in the treatment of hyperthyroidism and its influence on patients'serum FT4 and FT3 levels

作　　者：任秋颖 REN Qiu-ying(Xinmin People's Hospital,Xinmin 110300,China)

机构地区：[1]新民市人民医院内分泌,110300

出　　处：《中国实用医药》2021年第33期146-149,共4页China Practical Medicine

摘　　要：目的分析糖皮质激素联合甲巯咪唑治疗甲状腺功能亢进症(甲亢)的效果及对患者血清游离甲状腺素(FT_(4))、血清游离三碘甲腺原氨酸(FT_(3))水平的影响。方法78例甲亢患者,根据随机数字表法分为对照组和研究组,各39例。对照组患者给予甲巯咪唑治疗,研究组患者给予糖皮质激素联合甲巯咪唑治疗。比较两组患者临床疗效、不良反应发生情况及治疗前后甲状腺激素水平。结果治疗前,两组FT_(3)、FT_(4)、促甲状腺激素(TSH)水平比较,差异无统计学意义(P>0.05);治疗后,两组FT_(3)、FT_(4)、TSH水平均优于治疗前,且研究组FT_(3)(4.11±0.60)pmol/L、FT_(4)(13.20±0.41)pmol/L、TSH(2.65±0.88)mU/L均优于对照组的(7.62±0.61)pmol/L、(14.83±0.51)pmol/L、(2.15±0.28)mU/L,差异有统计学意义(P<0.05)。研究组总有效率为97.44%,高于对照组的74.36%,差异有统计学意义(P<0.05)。研究组不良反应发生率为5.13%,低于对照组的48.72%,差异有统计学意义(P<0.05)。结论甲亢患者采用糖皮质激素联合甲巯咪唑治疗可有效提高临床疗效,同时改善甲状腺激素水平,值得推广。Objective To analyze the effect of glucocorticoid combined with methimazole in the treatment of hyperthyroidism and its influence on patients' semm serum free thyroxine(FT_(4)),serum free triiociothyronine(FT_(3))levels.Methods A total of 78 patients with hyperthyroidism were divided into control group and research group according to the random numerical table,with 39 cases in each group.Patients in the control group were treated with methimazole,and patients in the research group were treated with glucocorticoid and methimazole.The clinical efficacy,occurrence of adverse reactions,and thyroid hormone levels before and after treatment were compared between the two groups.Results Before treatment,there was no statistically significant difference in the levels of FT_(3),FT_(4),and thyroid-stimulating hormone(TSH)between the two groups(P>0.05).After treatment,the FT_(3),FT_(4),and TSH levels of the two groups were better than those of this group before treatment,and the FT_(3)(4.11±0.60)pmol/L,FT_(4)(13.20±0.41)pmol/L,and TSH(2.65±0.88)mU/L of the research group were all better than(7.62±0.61)pmol/L,(14.83±0.51)pmol/L,(2.15±0.28)mU/L of the control group.All the differences were statistically significant(P<0.05).The total effective rate of the research group was 97.44%,which was higher than 74.36%of the control group,and the difference was statistically significant(P<0.05).The adverse reaction rate of the research group was 5.13%,which was lower than 48.72%of the control group,and the difference was statistically significant(P<0.05).Conclusion Glucocorticoid in combination with methimazole in the treatment of hyperthyroidism can effectively improve the clinical efficacy and thyroid hormone level,which is worthy of promotion.

关 键 词：甲状腺功能亢进症 甲巯咪唑 糖皮质激素 血清游离甲状腺素 血清游离三碘甲腺原氨酸 

分 类 号：R581.1[医药卫生—内分泌]