CLK与相关疾病的研究进展  

Research Progress in CLK and Related Diseases

作　　者：司文英 孟宪勇[2] 董晓华 SI Wen-ying;MENG Xian-yong;DONG Xiao-hua(Department of Pharmacy & Hebei Key Laboratory of Neuropharmacology,Hebei North University,Zhangjiakou,Hebei 075000,China;The First Affiliated Hospital of Hebei North University,Zhangjiakou,Hebei 075000,China)

机构地区：[1]河北北方学院药学系,河北省神经药理学重点实验室,河北张家口075000 [2]河北北方学院附属第一医院,河北张家口075000

出　　处：《河北北方学院学报（自然科学版）》2022年第2期51-56,共6页Journal of Hebei North University:Natural Science Edition

基　　金：河北省自然科学基金项目(No.H2019405081)。

摘　　要：Cdc2样激酶(cdc2-like kinases,CLK)属于CMGC组的丝氨酸/苏氨酸激酶。CLK家族包括CLK1、CLK2、CLK3和CLK4,这些激酶参与多种细胞功能,包括细胞内信号转导、hnRNA剪接、体温调节等。激酶的异常表达与多种疾病有关,如病毒感染、肿瘤、药物成瘾、神经系统疾病等。对CLK在相关疾病中的作用进行了总结。Cdc2-like kinases(CLK)belong to serine/threonine kinases.CLK family consists of CLK1,CLK2,CLK3 and CLK4.These kinases are involved in a variety of cellular functions,including intracellular signal transduction,hnRNA splicing,and thermoregulation.The abnormal expression of kinases is associated with many kinds of diseases,such as viral infection,tumor,drug addiction,nervous system disease,etc.The role of CLK in related diseases was summarized.

关 键 词：CLK 抗病毒 抗肿瘤 药物成瘾 神经系统疾病 

分 类 号：R392.12[医药卫生—免疫学]