60例血小板抗体初筛强阳性患儿的抗体效价分析  

Analysis of Antibody Titers of 60 Pediatric Patients with Strong Positive Platelet Antibody Screening Results

作　　者：邱立娟[1] 付晓艳 郭凯 王孟键 刘禹 马曙轩[1] QIU Li-juan;FU Xiao-yan;GUO Kai(Department of Blood Transfusion,Beijing Children's Hospital,Capital Medical University,National Center for Children's Health,Beijing 100045)

机构地区：[1]国家儿童医学中心首都医科大学附属北京儿童医院,北京100045

出　　处：《临床输血与检验》2021年第6期704-707,共4页Journal of Clinical Transfusion and Laboratory Medicine

摘　　要：目的探索血小板抗体初筛强阳性患儿抗体效价分布情况及影响因素。方法收集北京儿童医院2019年1月~2021年3月期间采用固相凝集法检测血小板抗体共21230例,结果其中抗体强阳性(4+)患儿60例。对强阳性血清倍比稀释后采用同样方法检测血小板抗体效价。按性别、年龄、有无输血史、疾病进行分组并比较各组效价差异。结果60例患儿效价分布范围2~64,其中效价为2、4、8、16、32、64的患儿分别为5例(8.33%)、8例(13.33%)、15例(25.00%)、21例(35.00%)、9例(15.00%)、2例(3.33%);血小板抗体效价在不同年龄、性别、输血史和不同疾病组间差异均无统计学意义(P>0.05)。结论儿科患者血小板抗体效价为8~16者占比较多,但效价高低与性别、年龄、有无输血史和临床疾病差异无统计学意义。Objective To explore the titer distribution and influencing factors of children with preliminary positive platelet antibody screening.Methods A total of 21230 cases of platelet antibodies were detected by solid phase agglutination method from January 2019 to March 2021 in Beijing Children's Hospital,and 60 children were strong positive(4+)of platelet antibody screening.The titers of the positive samples were tested by continuous dilution and solid phase agglutination.Then the differences of the titers were compared in different groups which were divided according to gender,age,blood transfusion history and diseases.Results The titer distribution range of 60 children was 2,4,8,16,32 and 64,which were 5 cases(8.33%),8 cases(13.33%),15 cases(25.00%),21 cases(35.00%),9 cases(15.00%)and 2 cases(3.33%)respectively.No significant differences among these groups(P>0.05)were found.Conclusion The titer range of children with strong positive platelet antibody is 8 to 16,but the level of titer is not statistically related to gender,age,blood transfusion history and clinical diseases.

关 键 词：儿童 固相凝集法 血小板抗体 效价 

分 类 号：R457[医药卫生—治疗学]