HIV合并结核患者CD4^(+)T细胞数、抗逆转录病毒治疗时机选择与结核相关免疫重建炎症综合征关系的Meta分析  

Association between CD4^(+)T cells,antiretroviral therapy timing and tuberculosis-associated immune reconstitution inflammatory syndrome in HIV patients with tuberculosis:a Meta analysis

作　　者：李晓亮 李佩珠 林娇如 高仲爱 张璟 LI Xiao-liang;LI Pei-zhu;LIN Jiao-ru;GAO Zhong-ai;ZHANG Jing(Department of Occupational Health,Zhuhai Center for Chronic Disease Control,Zhuhai 519000,China)

机构地区：[1]广东省珠海市慢性病防治中心职业卫生科,广东珠海519000

出　　处：《广东医科大学学报》2021年第6期692-696,共5页Journal of Guangdong Medical University

基　　金：珠海市医学科研基金项目(No.ZH3310200038PJL)。

摘　　要：目的系统评价艾滋病合并结核(TB-HIV)患者CD4+T细胞数、抗逆转录病毒疗法(ART)治疗时机选择与结核相关免疫重建炎症综合征(TB-IRIS)的关系。方法检索Pub Med和EMBASE数据库1980年1月-2019年12月英文文献,使用R语言Meta程序包V3.3.2进行分析。结果该次分析共纳入10个RCT研究共5226个研究对象。Meta分析结果显示低CD4+T细胞数和早期ART治疗可增加TB-IRIS发生率。结论CD4+T细胞数和接受ART治疗时机可影响TB-IRIS的发生率。Objective To evaluate the association between CD4^(+)T cells,antiretroviral therapy(ART)timing and tuberculosis-associated immune reconstitution inflammatory syndrome(TB-IRIS)in HIV patients with tuberculosis using a Meta analysis.Methods The English literatures between January 1980 and December 2019 were retrieved on PubMed and EMBASE,and analyzed using Meta package V3.3.2 in R.Results Ten RCT studies and 5,226 objects were included.Meta analysis showed that lower CD4^(+)T cells and early ART increased incidence of TB-IRIS.Conclusion CD4^(+)T cells and ART timing may affect the incidence of TB-IRIS.

关 键 词：CD4^(+)T细胞 抗逆转录病毒疗法 人类免疫缺陷病毒 META分析 

分 类 号：R511[医药卫生—内科学]