丝胶蛋白及其复合材料在软骨和骨组织工程中的研究进展  

Research progress of sericin and its composite materials in cartilage and bone tissue engineering

作　　者：刘苹 戴梦男 李蒙 宋慧 龚佳俊[1,2] 殷音 王建南[1,2] LIU Ping;DAI Mengnan;LI Meng;SONG Hui;GONG Jiajun;YIN Yin;WANG Jiannan(College of Textile and Clothing Engineering,Soochow University,Suzhou 215123,China;Key Laboratory of Textile Industry for Silk Products in Medical and Health Use,Soochow University,Suzhou 215123,China;Medical College,Soochow University,Suzhou 215123,China)

机构地区：[1]苏州大学纺织与服装工程学院,江苏苏州215123 [2]苏州大学纺织行业医疗健康用蚕丝制品重点实验室,江苏苏州215123 [3]苏州大学医学部,江苏苏州215123

出　　处：《丝绸》2021年第12期1-7,共7页Journal of Silk

基　　金：国家自然科学基金项目(51873141);江苏省自然科学基金项目(BK20181192);江苏省高等学校自然科学研究重大项目(18KJA540001)。

摘　　要：骨/软骨组织工程是结合医学与材料科学开发支架材料来治疗或替换坏损骨/软骨。丝胶蛋白生物学性能优异,在骨组织修复和软骨组织再生方面应用潜力巨大。研究显示,丝胶蛋白基骨组织工程支架可以促进细胞黏附与增殖、刺激胶原蛋白生成、并为磷酸钙提供成核位点来促进羟基磷灰石沉积;其溶液凝胶转变特性为包埋的细胞提供合适的生存环境。因此,文章综述了丝胶蛋白及其复合物在骨/软骨组织工程中的研究背景,重点阐述了丝胶蛋白材料的制备、生物矿化、与干细胞相互作用及对惰性金属骨移植物表面修饰等方面的研究进展,并对今后丝胶蛋白在骨和软骨组织工程方面的研究方向和发展做出展望。Bone/cartilage tissue engineering is the combination of medical science and material science to develop scaffold materials for the treatment or replacement of bone/cartilage defects.Sericin with excellent biological properties has tremendous potential in bone/cartilage tissue repair and regeneration.Studies have shown that sericin-based bone tissue engineering scaffold can promote cell adhesion and proliferation,stimulate collagen production,and provide nucleation bond for calcium phosphate to promote hydroxyapatite deposition.The solution-gel transition characteristics of sericin provide a suitable living environment for the embedded cells.Therefore,this article reviewed the research background of sericin and its composites in bone/cartilage tissue engineering,emphasized on the research progress in the sericin materials preparation,biomineralization,interaction with stem cells,and surface finishing on inert metal bone grafts.Finally,the article prospected the future research direction and development of sericin in bone/cartilage tissue engineering.

关 键 词：丝胶蛋白 骨 软骨 复合材料 组织工程 组织再生 

分 类 号：TS101.4[轻工技术与工程—纺织工程] Q189[轻工技术与工程—纺织科学与工程]