近年醇质体制备工艺及制剂研究进展  

Research Progress in Preparation and Pharmaceutical Dosage Forms of Ethosomes in Recent Years

作　　者：贺梦媛 丛竹凤[2] 张兵 高鹏[1] 高树中 HE Mengyuan;CONG Zhufeng;ZHANG Bing;GAO Peng;GAO Shuzhong(School of Pharmacy,Shandong University of Traditional Chinese Medicine,Jinan 250355;Shandong Provincial Institute of Cancer Prevention and Treatment,Jinan 250117;Shandong Center for Food and Drug Evaluation&Certification,Jinan 250014)

机构地区：[1]山东中医药大学药学院,山东济南250355 [2]山东省肿瘤防治研究院,山东济南250117 [3]山东省食品药品审评认证中心,山东济南250014

出　　处：《中国医药工业杂志》2021年第11期1409-1417,共9页Chinese Journal of Pharmaceuticals

基　　金：国家自然科学基金面上项目(81373721)。

摘　　要：醇质体是由磷脂、水和高浓度醇(乙醇、丙二醇或乙醇和丙二醇的混合物)组成的具有囊泡结构的新型脂质体,具有粒径小、药物包封率高、透皮吸收量高、易于制备等特点。本研究检索了2011至2020年以来国内外关于醇质体的文献报道,从醇质体的结构出发,结合研究趋势的转变总结醇质体的制备方法、工艺优化方法、促透技术及应用剂型,探究醇质体发展现状中存在的问题,以期为醇质体未来的研究方向提供参考。As a new type of liposomes with vesicle structure,ethosomes are composed of phospholipids,water and high-concentration alcohols(ethanol,propylene glycol,or a mixture of ethanol and propylene glycol).Ethosomes have the characteristics of small particle size,high drug entrapment efficiency,enhanced transdermal absorption,easy-to-prepare,etc.We retrieved the domestic and foreign literature reports on ethosomes from 2011 to 2020.On this basis,we summarized the preparation methods,optimization methods,penetration promotion technology and dosage forms of ethosomes,starting from analyzing compositions of ethosomes and the changes in research trends,and explored the existing problems in the development of ethosomes,so as to provide some references for future research directions of ethosomes.

关 键 词：醇质体 研究趋势 制备 优化 剂型 

分 类 号：R944.9[医药卫生—药剂学]