经皮肺动脉去交感神经冷冻消融术治疗犬肺动脉高压疗效评价  

Percutaneous Pulmonary Artery Denervation Cryoablation was Performed in Therapeutic Effect Evaluation of Canine Pulmonary Hypertension

作　　者：陈浩[1] 林衔亮 温福利[2] 薛来恩 陈璟 李林睿 吴晓娟 林涯泽 杨燊 CHEN Hao;LIN Xianliang;WEN Fuli;XUE Laien;CHEN Jing;LI Linrui;WU Xiaojuan;LIN Yaze;YANG Shen(Department of Cardiology,the 900^(th)Hospital of the Joint Logistics Team,PLA,Fuzhou 350025,China;Laboratory of Basic Medicine,900^(th)Hospital of the Joint Logistics Team,PLA,Fu-zhou 350025,China;Nursing Department of the 900^(th)Hospital of Joint Logistic Support Force of PLA,Fuzhou 350025,China;Affiliated Eastern Hospital of Xiamen University,Fuzhou 350025,China;Clinical Medical College of Fuzhou General Hospital of Fujian Medical University Fuzhou 350025,China)

机构地区：[1]中国人民解放军联勤保障部队第900医院心血管内科,福州350025 [2]中国人民解放军联勤保障部队第900医院基础医学实验室,福州350025 [3]中国人民解放军联勤保障部队第900医院护理部,福州350025 [4]厦门大学附属东方医院,福州350025 [5]福建医科大学福州总院临床医学院,福州350025

出　　处：《实验动物科学》2021年第5期15-18,共4页Laboratory Animal Science

基　　金：福建省自然基金资助项目(2017J01325)。

摘　　要：目的通过野百合碱诱导的犬肺动脉高压模型,观察肺动脉去交感神经冷冻消融术后6个月的肺动脉平均压力(m PAP)、肺毛细血管楔压(PCWP)及内皮素受体-1(ET-1)变化,评估冷冻消融去比格犬肺动脉交感神经的安全性和有效性。方法将15只比格犬随机分为A组(冷冻消融组)、B组(假手术组)及C组(对照组),对比观察比格犬手术前后m PAP、PCWP及ET-1水平变化。结果A、B和C各组术后6个月,m PAP、PCWP和ET-1值均低于术前水平,差异有统计学意义(P<0.05)。结论犬肺动脉高压经皮肺动脉去交感神经冷冻消融术安全且有效,术后表现出延续性降肺动脉压力效果。Objective To observe the changes of mean pulmonary artery pressure(m PAP),pulmonary capillary wedge pressure(PCWP)and endothelin receptor 1(ET-1)after 6 months of pulmonary artery denervation(PADN)cryoablation in canine model of pulmonary artenal hypertension induced by monocyrinine,and to evaluate the safety and efficacy of cryoablation denervation of pulmonary artery for beagle dogs.Method Fifteen beagles were randomly divided into group A(the cryoablation operation group),group B(the sham operation group)and group C(the blank control group),and each group with five dogs.The changes of m PAP,PCWP and ET-1 levels were observed after operation in beagles.Result Six months after surgery,the levels of m PAP,PCWP and ET-1 in groups A,B and C were lower than the preoperative level and the difference was statistically significant(P<0.05).Conclusion Percutaneous pulmonary artery denervation cryoablation of canine pulmonary hypertension is safe and effective.The postoperative result showed a continuous reduction of pulmonary artery pressure.

关 键 词：犬肺动脉高压 肺动脉去交感神经 冷冻消融 

分 类 号：R541[医药卫生—心血管疾病]