2017—2019年北京地区实验动物质量抽检结果分析  

Analysis of Random Testing Results of Laboratory Animals in Beijing Area from 2017 to 2019

作　　者：魏杰[1] 黄健 刘文菊[2] 付瑞[1] 邢进[1] 王洪[1] 王吉[1] 李晓波[1] 冯育芳[1] 王淑菁[1] 高强 王锡乐 巩薇[1] 贺争鸣[1] 李根平[2] 岳秉飞[1] WEI Jie;HUANG Jian;LIU Wenju;FU Rui;XING Jin';WANG Hong;WANG Ji;LI Xiaobo;FENG Yufang;WANG Shujing;GAO Qiang;WANG Xile;GONG Wei;HE Zhengming;LI Genping;YUE Bingfei(National Institute for Food and Drug Control,Bejing 102629,China;Beijing Administration Office of Laboratory Animal,Beijing 100195,China)

机构地区：[1]中国食品药品检定研究院,北京100050 [2]北京市实验动物管理办公室,北京100195

出　　处：《实验动物科学》2021年第5期19-27,58,共10页Laboratory Animal Science

基　　金：国家重点研发计划资助(2017YFD0501600)。

摘　　要：目的比对分析2017—2019年北京地区实验动物微生物及遗传质量监测结果,为实验动物产业发展提供参考。方法按照国家和地方现行实验动物检测标准,对北京地区实验动物生产单位进行抽检,并发布检测报告。按照报告数据,对此阶段小鼠、大鼠、豚鼠、地鼠、兔、犬、猴和小型猪共8个品种的实验动物按照品种、等级、单位等进行分类,分析质量问题,并与2014—2016年同期实验动物质量比对,分析变化趋势。结果2017—2019年分别抽检动物144、131和135批次,检出不合格批次分别为30、15和17批。不合格主要因素为兔、犬及猪免疫不达标(20批),病原感染20批,未发现遗传变异。与2014—2016年同期相比,未检出遗传问题相同,免疫不达标状况好转,但病原感染出现上升。结论通过质量分析比对,能够为实验动物产业健康发展提供数据支持。Objective To provide reference to production,management and detection of laboratory animals by comparative analyzing of the recently 3 years’test result from 2017 to 2019 on microbes and genetics of laboratory animals in Beijing area.Method According to the national and local standards,relevant law and regulation,the laboratory animal production units in Beijing area were randomly inspected and the tested.According to the data,8 species of the laboratory animals including mice,rats,guineas,shrews,rabbits,dogs,monkeys and minipigs were classified according to their breeds,grades,units,etc.,and their quality problems were analyzed.The change in trend analysis of the quality of the laboratory then was analyzed and compared with the same period from 2014 to2016.Result From 2017 to 2019,there were 144,131 and 135 batches of random testing annually,while 30,15 and 17 unqualified batches,respectively.The main reasons for disqualification were the immunity level dissatisfaction(20 batches in rabbits,dogs and minipigs)and 20 batches were infected by pathogens.No genetic variation was found.Compared with the relevant results from 2014 to 2016,no genetic problems have been detected.The status of substandard immunity has improved and pathogenic infections have increased.Conclusion This result can provide support to the healthy development of the laboratory animal industry.

关 键 词：北京 实验动物 质量监测 管理 

分 类 号：Q95-331[生物学—动物学]