精神分裂症动物模型的研究进展  

Research Progression of Animal Model in Schizophrenia

作　　者：王凤娟 于小亚 丁瑜[1] 张金玉[1] 袁宝[1] 胡进平[1] WANG Fengjuan;YU Xiaoya;DING Yu;ZHANG Jinyu;YUAN Bao;HU Jinping(College of Animal Sciences,Jilin University,Changchun 130062,China;Jilin Provincial Science and Technology innovation Platform Management Center,Changchun 130012,China)

机构地区：[1]吉林大学动物科学学院,长春130062 [2]吉林省科技创新平台管理中心,长春130012

出　　处：《实验动物科学》2021年第5期70-74,共5页Laboratory Animal Science

基　　金：吉林省科技发展计划项目(No.20200703006ZP)。

摘　　要：精神分裂症是一种复杂的重性精神病,持续性强。患者常常无法控制自己的情绪,出现被害妄想、厌世甚至自杀等行为。建立精神分裂症疾病动物模型能够有助于探索其发病机制,从而优化临床诊断和治疗方法。本文将从精神分裂症、精神分裂症理想动物模型、精神分裂症现有动物模型等方面进行论述,力求进一步完善精神分裂症动物模型,进而为研究精神分裂症发病机制以及新药的开发提供理论依据。Schizophrenia is a complex and persistent psychosis.Patients often can’t control their emotions,which leading to appear delusional,world-weary and even suicidal behavior.The establishment of animal models in schizophrenia plays an important role in studying the pathogenesis and treatment of schizophrenia.In order to promote the improvement of animal models in schizophrenia and provide theoretical basis of studying the pathogenesis and the development of new medicines in schizophrenia,this article introduces schizophrenia,the ideal animal models in schizophrenia,the existing animal models in schizophrenia and so on.

关 键 词：精神分裂症 动物模型 模型建立方法 

分 类 号：Q95-331[生物学—动物学]