Cytotoxic diaporindene and tenellone derivatives from the fungus Phomopsis lithocarpus  

作　　者：LIU Hui-Bo LIU Zhao-Ming CHEN Yu-Chan Tan Hai-Bo LI Sai-Ni LI Dong-Li LIU Hong-Xin ZHANG Wei-Min 

机构地区：[1]State Key Laboratory of Applied Microbiology Southern China,Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application,Guangdong Open Laboratory of Applied Microbiology,Institute of Microbiology,Guangdong Academy of Sciences,Guangzhou 510070,China [2]School of Chemical and Environmental Engineering,Wuyi University,Jiangmen 529020,China [3]Program for Natural Products Chemical Biology,Key Laboratory of Plant Resources Conservation and Sustainable Utilization,Guangdong Provincial Key Laboratory of Applied Botany,South China Botanical Garden,Chinese Academy of Sciences,Guangzhou 510650,China

出　　处：《Chinese Journal of Natural Medicines》2021年第11期874-880,共7页中国天然药物（英文版）

基　　金：This work was supported by Guangdong Provincial Special Fund for Marine Economic Development Project(No.GDNRC[2020]042);the National Natural Science Foundation of China(No.41906106);Guangdong Special Support Program(No.2019TQ05Y375);the Team Project of the Natural Science Foundation of Guangdong Province(No.2016A030312014);the GDAS'Project of Science and Technology Development(No.2019GDA-SYL-0103007).

摘　　要：Nine new compounds,including five natural rarely-occurring 2,3-dihydro-1H-indene derivatives named diaporindenes E−I(1−5),and four new benzophenone analogues named tenellones J−M(6−9)were isolated from the deep-sea sediment-derived fungus Phomopsis lithocarpus FS508.All the structures for these new compounds were fully characterized on the basis of spectroscopic data,NMR spectra,and ECD calculation and single-crystal X-ray diffraction analysis.The potential anti-tumor activities of compounds 1−9 against four tumor cell lines SF-268,MCF-7,HepG-2,and A549 were evaluated using the SRB method.Compound 7 exhibited cytotoxic activity against the SF-268 cell line with an IC50 value of 11.36μmol·L^(−1).

关 键 词：Deep-see-derived fungus Phomopsis lithocarpus 2 3-Dihydro-1H-indene isomers Benzophenone derivatives 

分 类 号：R284[医药卫生—中药学]