雌激素在正畸过程中对牙移动骨改建及牙根吸收的影响  

Effect of estrogen on bone remodeling and root resorption during orthodontics

作　　者：程艺 刘婷 郭玉静 孙小桐 毕蓝 张荣和[1] Cheng Yi;Liu Ting;Guo Yujing;Sun Xiaotong;Bi Lan;Zhang Ronghe(Department of Orthodontics,Binzhou Medical University Hospital,Binzhou 256600,Shandong Province,China)

机构地区：[1]滨州医学院附属医院口腔正畸科,山东省滨州市256600

出　　处：《中国组织工程研究》2022年第17期2782-2788,共7页Chinese Journal of Tissue Engineering Research

摘　　要：背景:正畸牙移动和正畸诱导牙根吸收是正畸治疗中的重要部分,雌激素可以通过影响牙周组织骨改建调节正畸牙移动速率并可能抑制正畸诱导的牙根吸收。目的:综述分析雌激素对正畸牙移动和正畸诱导牙根吸收的影响机制。方法:文章第一作者检索PubMed、中国知网、万方数据库收录的相关文献;英文检索词为"estrogen,orthodontic tooth movement,orthodontically induced root resorption,osteoclast,osteoblast,bone marrow mesenchymal stem cells";中文检索词为"雌激素、正畸牙移动、正畸诱导牙根吸收、成骨细胞、破骨细胞、骨髓间充质干细胞、牙周膜干细胞";最终纳入53篇文献进行归纳总结。结果与结论:(1)正畸牙移动是正畸治疗的重要组成部分,是在机械力作用下通过骨改建实现的,而牙槽骨改建是正畸牙移动的基础。(2)雌激素是骨组织改建的重要调节剂;雌激素通过多种途径和多种细胞因子抑制破骨细胞分化、延长破骨细胞寿命,促进成骨细胞增殖、分化及功能,从而抑制骨吸收促进骨生成,骨改建减少,正畸牙移动受到抑制。(3)雌激素可能主要通过对破牙骨质细胞的抑制作用,减少正畸诱导的牙根吸收,其中破骨细胞及破牙细胞的分化在牙齿移动及牙根吸收过程中有重要意义。(4)最近研究发现酪氨酸激酶是雌激素抑制人类破骨细胞分化、存活和功能的重要信号递质。(5)虽然对雌激素在骨改建及牙根吸收方面有了初步研究,但是哪种机制占主导作用未阐明,且多处于基础或动物研究阶段,尚需关于该方面机制研究及临床研究。BACKGROUND:Orthodontic tooth movement and orthodontic induced root resorption are an important part of orthodontic treatment.Estrogen can regulate the rate of orthodontic tooth movement by influencing the bone remodeling of periodontal tissue,thereby inhibiting orthodontic-induced root resorption.OBJECTIVE:To review the mechanism of estrogen underlying orthodontic tooth movement and orthodontic induction of root resorption.METHODS:The first author searched Pub Med,CNKI,and Wan Fang databases using the keywords of“estrogen;orthodontic tooth movement;orthodontically induced root resorption;osteoclast;osteoblast;bone marrow mesenchymal stem cells;periodontal ligament stem cells”in English and Chinese,respectively.Finally,53 articles were included for further review.RESULTS AND CONCLUSION:Orthodontic tooth movement is an important part of orthodontic treatment.It can be achieved through bone reconstruction under mechanical force,and alveolar bone reconstruction is the basis of orthodontic tooth movement.Estrogen acts as an important regulator of bone tissue remodeling.Estrogen inhibits osteoclast differentiation,prolongs the life span of osteoclasts,promotes the proliferation,differentiation and function of osteoblasts through a variety of pathways and multiple cytokines,thereby inhibiting bone resorption,promoting bone formation,reducing bone remodeling,and inhibiting orthodontic tooth movement.Estrogen may reduce orthodontics-induced dental root resorption by inhibiting cementoclasts.The differentiation of osteoclasts and odontoclasts is of great significance in the process of tooth movement and root resorption.Recent studies have found that tyrosine kinase acts as an important signal medium for estrogen to inhibit the differentiation,survival and function of human osteoclasts.Although preliminary studies on the role of estrogen in bone remodeling and tooth root resorption have been reported,which mechanism exerts the dominant role has not been elucidated,and most of them are at the stage of basic or animal res

关 键 词：雌激素 正畸牙移动 正畸诱导牙根吸收 成骨细胞 破骨细胞 骨髓间充质干细胞 牙周膜干细胞 

分 类 号：R459.9[医药卫生—治疗学] R363[医药卫生—临床医学]