血浆转化生长因子结合蛋白2联合鳞状细胞癌抗原检测在肺癌诊断中的应用价值  

The application value of plasma transforming growth factor binding protein 2 combined with squamous cell carcinoma antigen detection in the diagnosis of lung cancer

作　　者：黄强 柳啸 HUANG Qiang;LIU Xiao(Department of Clinical Laboratory,Community Healthcare Center of Changshou Street,Putuo District,Shanghai 200063 China)

机构地区：[1]上海市普陀区长寿街道社区卫生服务中心检验科,上海200063

出　　处：《检验医学与临床》2021年第24期3551-3553,3556,共4页Laboratory Medicine and Clinic

摘　　要：目的探讨血浆转化生长因子结合蛋白2(LTBP2)联合鳞状细胞癌抗原(SCC)检测在肺癌诊断中的应用价值。方法将2019年1月至2021年1月该院收治的原发性肺癌患者104例纳入研究作为肺癌组,另选取50例肺炎患者作为肺炎组,100例体检健康者作为健康对照组。采集上述人群血液标本,应用酶联免疫吸附试验(ELISA)和全自动化学发光仪分别检测血清LTBP2和SCC水平。分析血清LTBP2水平与肺癌患者临床特征的关系。采用受试者工作特征(ROC)曲线分析血清LTBP2和SCC水平检测用于肺癌诊断的价值。结果肺癌组血清LTBP2及SCC水平均高于肺炎组和健康对照组(P<0.05)。TNM分期Ⅲ~Ⅳ期、有淋巴结转移、深层浸润的肺癌患者血清LTBP2水平较高(P<0.05)。血清LTBP2水平检测用于诊断肺癌的曲线下面积(AUC)为0.842(95%CI:0.704~0.916),灵敏度为89.15%,特异度为83.94%;血清SCC用于肺癌诊断的AUC为0.794(95%CI:0.529~0.843),灵敏度为82.17%,特异度为70.63%。血清LTBP2和SCC联合检测用于肺癌诊断的AUC为0.887(95%CI:0.752~0.974),灵敏度为92.67%,特异度为86.63%。结论原发性肺癌患者血清LTBP2水平升高,可能与肺癌的发生及进展有关,LTBP2联合SCC检测更利于临床肺癌的鉴别诊断。Objective To explore the application value of plasma transforming growth factor binding protein 2(LTBP2)combined with squamous cell carcinoma antigen(SCC)detection in the diagnosis of lung cancer.Methods A total of 104 patients with primary lung cancer admitted to the hospital from January 2019 to January 2021 were enrolled in the study as lung cancer group.In addition to that,50 patients with pneumonia were enrolled as pneumonia group,and 100 healthy people who underwent physical examination were enrolled as healthy control group.Collect blood samples from those people.Enzyme-linked immunosorbent assay(ELISA)and automatic chemiluminescence instrument were used to detect serum LTBP2 and SCC levels respectively.Analyze the relationship between serum LTBP2 levels and clinical characteristics of lung cancer patients.The receiver operating characteristic(ROC)curve was used to analyze the value of serum LTBP2 and SCC levels in the diagnosis of lung cancer.Results Serum LTBP2 and SCC levels in the lung cancer group were higher than those in the pneumonia group and the healthy control group(P<0.05).The serum LTBP2 levels were higher in patients with lung cancer with TNM stageⅢ-Ⅳ,lymph node metastasis,and deep invasion(P<0.05).The area under the curve(AUC)of serum LTBP2 level for the diagnosis of lung cancer was 0.842(95%CI:0.704-0.916),the sensitivity was 89.15%,and the specificity was 83.94%;the AUC of serum SCC for lung cancer diagnosis was 0.794(95%CI:0.529-0.843),the sensitivity is 82.17%,and the specificity is 70.63%.The AUC of the combined detection of serum LTBP2 and SCC for lung cancer diagnosis was 0.887(95%CI:0.752-0.974),the sensitivity was 92.67%,and the specificity was 86.63%.Conclusion The elevated serum LTBP2 level in patients with primary lung cancer may be related to the occurrence and progression of lung cancer.LTBP2 combined with SCC detection is more conducive to the differential diagnosis of clinical lung cancer.

关 键 词：转化生长因子结合蛋白2 鳞状细胞癌抗原 肺癌 

分 类 号：R446.11[医药卫生—诊断学]