血清IgE、BNP水平用于心力衰竭诊断的价值及其与部分血脂、心功能指标的相关性  

The diagnostic value of serum IgE and BNP levels in heart failure and their correlation with some blood lipids or cardiac function indicators

作　　者：赵鑫[1] 朱蕾[1] 强雪芹 ZHAO Xin;ZHU Lei;QIANG Xueqin(Chengdu Seventh People′s Hospital,Chengdu,Sichuan 610000,China)

机构地区：[1]四川省成都市第七人民医院,四川成都610000

出　　处：《检验医学与临床》2021年第24期3591-3594,共4页Laboratory Medicine and Clinic

摘　　要：目的探讨血清免疫球蛋白E(IgE)、脑钠肽(BNP)水平检测对心力衰竭的诊断价值及其与部分血脂、心功能指标的相关性。方法将2018年10月至2020年10月该院收治的100例心力衰竭患者作为心力衰竭组,选取同期确诊的冠心病患者100例作为冠心病组,另选取90例健康者作为对照组。对3组的左心室结构指标、血脂指标[包括低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)]及血清IgE、BNP、超敏C反应蛋白(hs-CRP)水平进行比较。分析心力衰竭患者血清IgE、BNP水平与其他指标的相关性。分析血清IgE、BNP单独及联合检测对心力衰竭的诊断效能。结果心力衰竭组左室舒张末期内径、左室收缩末期内径值均高于冠心病组和对照组(P<0.05),而左室射血分数小于冠心病组和对照组(P<0.05)。心力衰竭组、冠心病组HDL-C水平均低于对照组(P<0.05),血清LDL-C、IgE、BNP、hs-CRP水平均高于对照组(P<0.05)。心力衰竭患者血清IgE与NBP水平呈正相关(r=0.325,P<0.05),与LDL-C水平呈负相关(r=-0.297,P<0.05);BNP与左室舒张末期内径、左室收缩末期内径呈正相关(r=0.345、0.427,P<0.05)。IgE检测的灵敏度、特异度分别为91.6%、53.6%,BNP检测的灵敏度、特异度分别为84.9%、92.5%,IgE、BNP联合检测的灵敏度、特异度分别为92.3%、93.0%,联合检测的灵敏度、特异度均高于单项检测(P<0.05)。结论血清IgE、BNP水平与部分血脂或心功能指标相关,IgE、BNP联合检测可提高心力衰竭的诊断效能。Objective To investigate the diagnostic value of serum immunoglobulin E(IgE)and brain natriuretic peptide(BNP)levels in heart failure and their correlation with some blood lipids and cardiac function indicators.Methods A total of 100 patients with heart failure treated in the hospital from October 2018 to October 2020 were enrolled as the heart failure group,100 patients diagnosed with coronary heart disease in the same period were enrolled as the coronary heart disease group,and 90 healthy people were enrolled as the control group.The left ventricular structural indicators,serum lipid indicators(including LDL-C and HDL-C),serum IgE,BNP,high-sensitivity C-reactive protein(hs-CRP)levels were compared among the three groups.The correlation between serum IgE,BNP levels and other indicators in patients with heart failure and the diagnostic efficacy of serum IgE and BNP alone and combined for heart failure were analyzed.Results The left ventricular end-diastolic diameter and left ventricular end-systolic diameter in the heart failure group were higher than those in the coronary heart disease group and the control group(P<0.05),while the left ventricular ejection fraction were lower(P<0.05).The HDL-C levels of the heart failure group and the coronary heart disease group were lower than those of the control group(P<0.05),and the serum LDL-C,IgE,BNP,and hs-CRP levels were higher than those of the control group(P<0.05).The serum IgE level was positively correlated with NBP in patients with heart failure(r=0.325,P<0.05),and negatively correlated with LDL-C(r=-0.297,P<0.05).BNP was correlated with left ventricular end-diastolic diameter,and left ventricular end-systolic diameter respectively(r=0.345,0.427,P<0.05).The sensitivity and specificity of IgE detection were 91.6%and 53.6%respectively.The sensitivity and specificity of BNP detection were 84.9%and 92.5%,respectively.The sensitivity and specificity of IgE and BNP combined detection were 92.3%and 93.0%,respectively.The sensitivity and specificity of the combined detect

关 键 词：心力衰竭 免疫球蛋白E 脑钠肽 左心室结构 血脂 诊断效能 

分 类 号：R446.11[医药卫生—诊断学]