癫痫放电引起的HRF函数变化的仿真研究  

Simulation study on Change of HRF Function Caused by Epileptic Discharge

作　　者：薛开庆 张涛 XUE Kai-qing;ZHANG Tao(School of Computer Science and Software Engineering,Xihua University,Chengdu Sichuan 610039,China;Mental Health Service and Research Center,Xihua University,Chengdu Sichuan 610039,China)

机构地区：[1]西华大学计算机与软件工程学院,四川成都610039 [2]西华大学心理健康服务与研究中心,四川成都610039

出　　处：《计算机仿真》2021年第11期240-243,248,共5页Computer Simulation

基　　金：国家自然科学基金青年基金项目(62006197);四川省教育厅科研项目(15226431,18SB0596);西华大学校重点科研基金项目(z1422614);省级学科开放平台基金项目(szjj2015-063);教育部春晖计划合作科研项目(z2017078)。

摘　　要：血氧动力学响应函数反映的是在单位强度的瞬时刺激下诱发的血氧水平依赖信号的动态响应过程。在探索中枢神经系统激活的动力学过程中,如何认识和理解血氧动力学响应函数是其中的一个关键问题。采用同步EEG-fMRI方法,把癫痫发作放电看作单位强度的瞬时刺激,用来探讨儿童良性癫痫患者的血氧动力学响应函数。癫痫患者的血氧动力学响应函数与其它几种函数仿真的结果进行比较,发现了其中的差异。要获得更加准确的结果必须进一步获取被试个性化的血氧动力学响应函数。The hemodynamic response function reflects the dynamic response process of blood oxygen level dependent signal induced by instantaneous stimulus per unit intensity. In the process of exploring the dynamics of central nervous system activation, how to recognize and understand the hemodynamic response function is one of the key issues. In this study, EEG-fMRI method was used to investigate the hemodynamic response function of benign epilepsy in children by regarding the epileptic discharge as instaneous stimulation of unit intensity. The hemodynamic response function of patients with epilepsy was compared with the results of several other simulations, and the differences were found. In order to obtain more accurate results, it is necessary to further obtain the individual’s blood oxygen dynamic response function of the subjects.

关 键 词：功能磁共振 脑电 痫性放电 血氧动力学响应函数 

分 类 号：TP391.9[自动化与计算机技术—计算机应用技术]