lncRNA在动物脂肪沉积中的研究进展  

Research Progress of lncRNA in Animal Fat Deposition

作　　者：刘天义 冯卉 SALSABEEL Yousuf 解领丽 苗向阳[1] LIU Tian-yi;FENG Hui;SALSABEEL Yousuf;XIE Ling-li;MIAO Xiang-yang(Institute of Animal Sciences of Chinese Academy of Agricultural Sciences,Beijing 100193,China)

机构地区：[1]中国农业科学院北京畜牧兽医研究所,北京100193

出　　处：《中国生物工程杂志》2021年第11期82-88,共7页China Biotechnology

基　　金：国家转基因生物新品种培育重大专项(2009ZXZ08008-004、2008ZX08008-003);农业科技创新工程(ASTIP-IAS05);中央级公益性科研院所基本科研业务费专项(Y2016JC22、Y2018PT68)资助项目。

摘　　要：长链非编码RNA(long non-coding RNA,lncRNA),是一种长度大于200个核苷酸的调控性非编码RNA,能在转录水平、转录后水平及表观遗传水平等多个层面影响基因的表达。脂肪生成是一个复杂而有序的过程。大量研究表明,lncRNA在脂肪生成过程中扮演着重要角色,它可以影响脂质代谢及成脂分化等多种生物过程,从而间接影响肉品质。这对于提高畜禽肉品质、避免养殖业饲料过多转化成脂肪所导致的浪费以及对预防和治疗与脂肪代谢相关的疾病都具有重要意义。对lncRNA的基本特征、在动物脂肪沉积中的作用进展进行了综述,以期为培育优质畜禽,预防和治疗与脂肪代谢相关的疾病提供理论依据。Long non-coding RNA(lncRNA)is a regulatory non-coding RNA with a length of more than 200 nucleotides,which can be used at the transcription level,post-transcriptional level,and epigenetic level to affect gene expression.Lipogenesis is a complex and orderly process.A large number of studies have shown that lncRNA plays an important role in the process of adipogenesis.It can affect various biological processes such as lipid metabolism and adipogenic differentiation,thereby indirectly affecting meat quality.This is of great significance for improving the quality of livestock and poultry meat,avoiding the waste caused by excessive conversion of feed into fat in the breeding industry,and preventing and treating diseases related to fat metabolism.This article reviews the basic characteristics of lncRNA and the progress of its role in animal fat deposition,in order to provide a theoretical basis for cultivating high-quality livestock and poultry,preventing and treating diseases related to fat metabolism.

关 键 词：长链非编码RNA 脂肪 分化 脂代谢 

分 类 号：Q819[生物学—生物工程]