基于改善抗肿瘤药物疗效的聚合物混合胶束研究进展  

Research progress of polymer mixed micelles based on improving the efficacy of antitumor drugs

作　　者：柯仲成[1] 孙银宇 程小玲 张振海 王欢 李长江[1] 贾晓斌 KE Zhong-cheng;SUN Yin-yu;CHENG Xiao-ling;ZHANG Zhen-hai;WANG Huan;Li Chang-jiang;JIA Xiao-bin(Research Center of Chinese Medicine Efficacy and Health Technology,Huangs han University,Huangshan 245041,China;Health Supervision Institute of Turixi,Huangshan 245000,China;College of Traditional Chinese Medicine,China Pharmaceutical University,Nanjing 211198,China)

机构地区：[1]黄山学院中药功效与健康技术研究中心,安徽黄山245041 [2]黄山市屯溪区卫生监督所,安徽黄山245000 [3]中国药科大学中药学院,江苏南京211198

出　　处：《药学学报》2021年第11期3047-3059,共13页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目(81573620);安徽省自然科学基金面上项目(20080805MH269);安徽教育厅省级教学研究团队(2020jxtd250);安徽省教育厅教学研究重点项目(2020jyxm1766);安徽省教育厅自然科学研究一般项目(KJHS2019B07);国家级大学生创新创业训练项目(202010375037)。

摘　　要：聚合物胶束已成为一种很有潜力的药物载体,然而部分单聚合物胶束往往存在一些性能缺陷,如载药量偏低、稳定性不佳和微环境响应能力弱等。采用两种或两种以上高分子聚合物自组装形成的混合聚合物胶束是解决这些问题的有效方法。本文尝试从聚合物混合胶束的分子间作用力、制备表征、性能优势和生物活性等方面进行综述,展示聚合物混合胶束的优势,分析存在的问题和不足,希望为抗肿瘤纳米胶束的发展提供借鉴。Polymeric micelles have become a potential drug carrier. However, some single-copolymer micelles often have some performance defects, such as low drug loading, poor stability and weak response to microenvironment. Mixed micelles self-assembled from two or more dissimilar macromolecular polymers provides a direct and convenient approach to improve drug delivery. This paper attempts to review the internal force, preparation and characterization, performance advantages and biological activity of mixed polymer micelles, aims to show the advantages of polymer mixed micelles, analyzes the problems and shortcomings, and hopes to provide reference for the development of anti-tumor nano-micelles.

关 键 词：混合聚合物胶束 单聚合物胶束 抗肿瘤 载体材料 

分 类 号：R943[医药卫生—药剂学]