益气活血中药方辅助尼可地尔在心绞痛中的应用评价  

Evaluation of the Application of Chinese Herbal Medicine for Replenishing Qi and Activating Blood to Assist Nicorandil in the Treatment of Angina Pectoris

作　　者：耿百乐 田军彪[2] 贾海忠 GENG Baile;TIAN Junbiao;JIA Haizhong(Geriatric Ward,Beijing Gulou Hospital of Traditional Chinese Medicine,Beijing 100010,China;Department of Encephalopathy,Hebei Hospital of Traditional Chinese Medicine,Shijiazhuang,Hebei 050000,China;Department of Cardiology,China-Japan Friendship Hospital,Beijing 100010,China)

机构地区：[1]北京市鼓楼中医医院老年病区,北京100010 [2]河北省中医院脑病科,河北石家庄050000 [3]北京中日友好医院心内科,北京100010

出　　处：《湖南中医药大学学报》2021年第12期1930-1935,共6页Journal of Hunan University of Chinese Medicine

基　　金：河北省重点研发计划项目(20377710D)。

摘　　要：目的探讨益气活血中药方辅助尼可地尔在稳定型/不稳定型心绞痛中的应用效果。方法前瞻性选取2020年6月~2021年5月我院收治的126例稳定型/不稳定型心绞痛患者,应用随机数字表法将患者分为尼可地尔组、联合组,各63例,分别给予尼可地尔、尼可地尔联合益气活血中药方。治疗1个月后比较两组疗效、安全性。结果联合组总有效率(93.65%)高于尼可地尔组(80.95%)(P<0.05);联合组治疗后胸痛、胸闷、气短、乏力、四肢末端紫绀、舌有瘀斑瘀点评分、心肌缺血总负荷、ST段压低发生次数、ST段压低累计持续时间、血细胞比容、全血低切黏度、全血高切黏度、血浆黏度、活化血小板糖基化复合物(glycopropean complex of activated platelets,PAC-1)、血小板颗粒膜蛋白(lysosome intact membrane protein,CD63)、血栓素A2(thromboxane A2,TXA2)、血小板颗粒表面膜糖蛋白(alpha-granular membraneprotein,CD62P)、血小板聚集率(platelet aggregation rate,PagT)低于尼可地尔组(P<0.05)。结论益气活血中药方辅助尼可地尔治疗稳定型/不稳定型心绞痛,能增强疗效,改善心电图表现、血液流变学,预防血栓形成,安全可靠。Objective To investigate the effect of supplementing Qi and activating blood circulation Chinese medicine assisted nicorandil in the treatment of stable/unstable angina pectoris.Methods 126 patients with stable/unstable angina pectoris treated in our hospital from June 2020 to May 2021 were prospectively selected.Using computer random number table method,they were divided into nicorandil group and combined group,with 63 cases in each group.They were given nicorandil and nicorandil combined with traditional Chinese medicine for supplementing Qi and activating blood circulation respectively.After one month of treatment,the efficacy and safety of the two groups were compared.Results The total effective rate of combined group(93.65%)was higher than that of nicorandil group(80.95%)(P<0.05);after treatment,the combined group had chest pain,chest tightness,shortness of breath,fatigue,cyanosis at the end of limbs,ecchymosis score of tongue,total load of myocardial ischemia,occurrence times of ST segment depression,cumulative duration of ST segment depression,hematocrit,whole blood low shear viscosity,whole blood high shear viscosity,plasma viscosity and glycopropean complex of activated platelets(PAC-1),lysosome intact membrane protein(CD63),thromboxane A2(TXA2),alpha-granular membraneprotein(CD62P),platelet aggregation rate(PagT)were lower than nicorandil group(P<0.05).Conclusion Supplementing Qi and activating blood circulation Chinese medicine combined with nicorandil in the treatment of stable/unstable angina pectoris can enhance the curative effect,improve electrocardiogram performance and hemorheology,and prevent thrombosis,which is safe and reliable.

关 键 词：益气活血中药方 尼可地尔 冠心病 心电图ST段变化 血液流变学 血栓指标 

分 类 号：R259[医药卫生—中西医结合]