检索规则说明:AND代表“并且”;OR代表“或者”;NOT代表“不包含”;(注意必须大写,运算符两边需空一格)
检 索 范 例 :范例一: (K=图书馆学 OR K=情报学) AND A=范并思 范例二:J=计算机应用与软件 AND (U=C++ OR U=Basic) NOT M=Visual
作 者:刘燕晶 张帆[1] LIU Yan-jing;ZHANG Fan(Department of Endocrinology,Peking University Shenzhen Hospital,Shenzhen 518000,Guangdong Province,China)
机构地区:[1]广东省北京大学深圳医院内分泌科,广东深圳518000
出 处:《罕少疾病杂志》2022年第1期89-92,共4页Journal of Rare and Uncommon Diseases
摘 要:目的对2010年1月至2019年7月发表的暴发性1型糖尿病(FT1DM)个案共81篇116例患者临床特征进行分析和探讨。方法回顾性分析116例患者的临床资料,总结其临床特点。结果男女发病比例为1∶1.17,女性患者发病更早[(31.20±11.24)岁vs(36.93±15.24)岁],均于1周内出现DKA。部分患者伴有前驱感染症状、消化系统症状及三多一少症状。女性患者发病时血糖较低[(34.40±9.75)mmol/L vs(38.77±13.54)mmol/L],HbA1c水平4.6%~8.6%,且女性患者空腹C肽水平更低[(0.03±0.06)mmol/L vs(0.06±0.09)ng/mL],胰岛功能几乎完全丧失。少部分患者T1DM自身抗体阳性。多数患者使用胰岛素强化替代治疗。结论FT1DM病情危重,进展迅速,需长期使用外源性胰岛素替代治疗,应引起高度重视。Objective To analyse and explore clinical characteristics of 116 patients with fulminant type 1 diabetes mellitus(FT1DM)published from January 2010 to July 2019.Methods The chinical data of 116 patients were analyzed retrospectively,and the clinical features were summarized.Results The incidence ratio of male to female was 1:1.17,and women get sick earlier[(31.20±11.24)vs.(36.93±15.24)years old].All patients presented with ketoacidosis within one week.Some patients had prodromal infection symptoms,digestive system symptoms or diabetes symptoms.Women suffer from lower blood sugar levels than men[(34.40±9.75)vs.(38.77±13.54)mmol/L].The range of HbA1c level was 4.6%-8.6%.Women suffer from lower fasting c-peptide levels than men[(0.03±0.06)vs.(0.06±0.09)ng/mL].Pancreatic beta cells were rapidly destroyed.Some patients’T1DM autoantibody were positive.Most patients need long-term insulin replacement therapy.Conclusion FT1DM has remarkably abrupt onset and lifelong injection of exogenous insulin is inevitable.Physicians should sharpen their awareness of FT1DM.
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在链接到云南高校图书馆文献保障联盟下载...
云南高校图书馆联盟文献共享服务平台 版权所有©
您的IP:216.73.216.33