新疆某市不同艾滋病抗病毒治疗模式病毒学效果及疗效保持率  

Study on the curative effect of different treatment modes of HIV/AIDS antiretroviral therapy and efficacy maintenance rate in Xinjiang

作　　者：陆娟 张庆慧 潘珂君[3] 钟吉善 祖丽比亚·买买提艾力 王珂 LU Juan;ZHANG Qinghui;PAN Kejun;ZHONG Jishan;ZULIBIYA·Mammateli;WANG Ke(The Eighth Affiliated Hospital of Xinjiang Medical University,Urumqi 830013,China;The Second People's Hospital of Kuche City,Kuche 842000;Infection Department of the First Affiliated Hospital of Xinjiang Medical University,Urumqi 830054;Institute for Maternal and Child Health of Guangdong Province,Guangzhou 511400)

机构地区：[1]新疆医科大学第八附属医院,乌鲁木齐830013 [2]库车市第二人民医院,新疆库车842000 [3]新疆医科大学第一附属医院,乌鲁木齐830054 [4]广东省妇幼保健院,广州511400

出　　处：《中国艾滋病性病》2021年第11期1229-1232,共4页Chinese Journal of Aids & STD

基　　金：新疆维吾尔自治区自然科学基金(2017D01A64)。

摘　　要：目的通过对不同治疗模式的艾滋病ART效果、影响因素和疗效保持率进行分析,对当地现行治疗模式进行评价。方法选择2017-2020年在当地现行两种(门诊治疗和社区治疗)治疗模式下治疗的患者,利用艾滋病综合信息系统工作数据和患者其他的临床资料及ART数据,对治疗有效率、疗效保持率及其影响因素进行描述与分析,并对两种治疗模式进行评价。结果1867名患者符合研究条件,其中门诊组538人,社区组1329人。2020年在治患者治疗有效率门诊组(87.2%)高于社区组(82.8%),但多因素分析结果显示不同治疗模式与治疗有效率不相关。疗效的影响因素有婚姻状态、传播途径和从确认到治疗的时间间隔。门诊组和社区组两种治疗模式2年疗效保持率分别为75.1%和71.0%(χ^(2)=2.715,P=0.099),3年疗效保持率分别为71.0%和66.3%(χ^(2)=3.539,P=0.111),4年疗效保持率分别为65.5%和59.0%(χ^(2)=1.984,P=0.159)。2~4年的疗效保持率差异均无统计学意义。结论从长期看社区治疗有效率和疗效保持率并不低于在定点医院门诊治疗。社区治疗是一种可以为治疗情况稳定的患者提供长期而便利且有效的治疗方式,值得在医疗人力资源有限的地区推广。Objective To analyze the HIV/AIDS ART effect,influencing factors,and efficacy retention rate of different treatment modes,evaluation of the local current treatment modes in Xinjiang.Methods The patients treated under the current two local treatment modes(outpatient treatment and community treatment)from 2017 to 2020 were selected.The operational data of the AIDS comprehensive information system and other clinical data and ART data of patients were used to describe and analyze the effective rate,curative effect retention rate,and influencing factors,and the two treatment modes were evaluated.Results 1867 patients met the study conditions,including 538 outpatients and 1329 community patients.In 2020,the effective rate of the outpatient treatment group(87.2%)was higher than that of the community treatment group(82.8%).Still,the results of multivariate analysis showed that different treatment modes were not related to the effective rate of treatment.The influencing factors include marital status,route of transmission,and interval from confirmation to treatment.The 2-year efficacy retention rates of outpatient group and community group were 75.1%and 71.0%(χ^(2)=2.715,P=0.099),3-year efficacy retention rates were 71.0% and 66.3%(χ^(2)=3.539,P=0.111),and 4-year efficacy retention rates were 65.5% and 59.0%(χ^(2)=1.984,P=0.159).There was no significant difference in the efficacy retention rate between 2-4 years.Conclusion In the long run,the effective rate and efficacy maintenance rate of community treatment are not lower than outpatient treatment in outpatient designated hospitals.Community therapy is a long-term,convenient and effective treatment for patients with stable treatment,worthy of promotion in areas with limited medical human resources.

关 键 词：艾滋病 抗病毒治疗模式 疗效保持率 影响因素 

分 类 号：R512.91[医药卫生—内科学]