清金保肺方联合阿奇霉素治疗小儿支原体肺炎痰热闭肺证59例临床观察  

Clinical observation on 59 cases of mycoplasma pneumoniae in children with phlegm-heat obstructing lung syndrome treated by Qingjin Baofei Fang(清金保肺方)combined with azithromycin

作　　者：崔利萍 崔艳花 侯立功 CUI Liping;CUI Yanhua;HOU Ligong(Department of General Internal Medicine,Children’s Hospital Affiliated to Zhengzhou University/Henan Children’s Hospital/Zhengzhou Children’s Hospital,Zhengzhou,Henan,450002,China;Department of Pediatrics,Zhengzhou The First People’s Hospital,Zhengzhou,Henan,450006,China)

机构地区：[1]郑州大学附属儿童医院/河南省儿童医院/郑州儿童医院普内科,河南郑州450002 [2]郑州市第一人民医院儿科,河南郑州450006

出　　处：《中医儿科杂志》2021年第6期53-57,共5页Journal of Pediatrics of Traditional Chinese Medicine

摘　　要：目的观察清金保肺方联合阿奇霉素治疗小儿支原体肺炎(MPP)痰热闭肺证的临床疗效。方法选取2020年1—10月郑州儿童医院普内科收治的120例MPP痰热闭肺证患儿,采用随机数字表法分为对照组和治疗组,各60例。对照组给予阿奇霉素,治疗组在对照组治疗方法的基础上给予清金保肺方,2组均治疗13 d后统计临床疗效,治疗前后肺功能指标呼气达峰时间(TPTEF)、达峰容积比(PFV)、呼气达峰容积(VPTEF)、呼气峰值流速(PEF)变化,血气分析指标血氧分压(O_(2)分压)、二氧化碳分压(CO_(2)分压)、血红蛋白(Hb)、血氧饱和度(SaO_(2))水平,血清炎症因子肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、C-反应蛋白(CRP)水平以及2组不良反应发生情况。结果治疗组总有效率为96.61%(57/59),显著高于对照组的80.70%(46/57),2组比较,差异有统计学意义(P<0.05)。治疗前,2组肺功能指标TPTEF、PFV、VPTEF、PEF水平比较,差异无统计学意义(P>0.05),具有可比性;治疗后,2组上述指标水平与同组治疗前比较,均明显升高(P<0.05),且治疗组升高更显著,差异有统计学意义(P<0.05)。治疗前,2组O_(2)分压、CO_(2)分压、Hb、SaO_(2)水平比较,差异无统计学意义(P>0.05),具有可比性;治疗后,2组上述指标水平与同组治疗前比较,均明显升高(P<0.05),且治疗组升高更显著,差异有统计学意义(P<0.05)。治疗前,2组炎症因子TNF-α、IL-6、IL-8、CRP水平比较,差异无统计学意义(P>0.05),具有可比性;治疗后,2组上述炎症因子水平与同组治疗前比较,均显著降低(P<0.05),且治疗组降低更显著,差异有统计学意义(P<0.05)。对照组不良反应总发生率为28.07%(16/57),治疗组为28.80%(17/59),2组比较,差异无统计学意义(P>0.05)。结论清金保肺方联合阿奇霉素治疗小儿MPP痰热闭肺证,不仅可有效改善患儿的肺功能指标,增加机体供氧量,改善呼吸功能,而且可抑制炎症�Objective To observe the clinical efficacy of Qingjin Baofei Fang(清金保肺方)combined with azithromycin in the treatment of mycoplasma pneumoniae(MPP)in children with phlegm-heat obstructing lung syndrome.Methods From January to October 2020,120 cases of MPP in children with phlegm-heat obstructing lung syndrome admitted into general internal medicine department of Zhengzhou Children’s Hospital were divided into control group and treatment group according to random number table method,with 60 cases in each group.The control group was given azithromycin,on this basis,the treatment group was given Qingjin Baofei Fang.After both groups were treated for 13 days,we kept statistics about the clinical efficacy,pulmonary function indices changes including time to peak tidal expiratory flow(TPTEF),volume ratio in peak flow(PFV),volume in peak time of expiratory flow(VPTEF),peak expiratory flow(PEF),the levels of blood gas analysis indices including blood oxygen partial pressure(O_(2) partial pressure),partial pressure of carbon dioxide(CO_(2) partial pressure),hemoglobin(Hb),and degree of blood oxygen saturation(SaO_(2)),the levels of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),interleukin-8(IL-8),c-reactive protein(CRP)before and after treatment,along with the incidence of adverse reactions of the 2 groups.Results The total effective rate of the treatment group was 96.61%(57/59),which was significantly higher than 80.70%(46/57)of the control group,and the difference was statistically significant between the 2 groups(P<0.05).Before treatment,there was no significant difference in the levels of TPTEF,PFV,VPTEF and PEF between the 2 groups(P>0.05),indicating comparability.After treatment,the levels of above-mentioned indices in both groups increased significantly than those in the same group before treatment(P<0.05),and the increase in the treatment group was more significant,and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in levels of O_(2) parti

关 键 词：小儿支原体肺炎 痰热闭肺证 清金保肺方 阿奇霉素 临床观察 

分 类 号：R725.6[医药卫生—儿科]