乙型肝炎疫苗免疫无/低应答影响因素的研究进展  

Progress in research of influential factors for non-or low-immune response to hepatitis B vaccination

作　　者：李娟[1] 魏明伟[2] 朱凤才[1,2,3] Li Juan;Wei Mingwei;Zhu Fengcai(School of Public Health,Nanjing Medical University,Nanjing 211166,China;Department of Vaccine Clinical Evaluation,Jiangsu Provincial Center for Disease Control and Prevention,Nanjing 210009,China;National Health Commission Key Laboratory of Enteric Pathogenic Microbiology,Jiangsu Provincial Center for Disease Control and Prevention/Center for Global Health,Nanjing Medical University,Nanjing 211166,China)

机构地区：[1]南京医科大学公共卫生学院,211166 [2]江苏省疾病预防控制中心疫苗临床评价所,南京210009 [3]江苏省疾病预防控制中心国家卫生健康委员会肠道病原微生物重点实验室/南京医科大学全球健康中心,南京211166

出　　处：《中华流行病学杂志》2021年第11期2066-2070,共5页Chinese Journal of Epidemiology

摘　　要：HBV使感染者罹患多种乙肝相关性疾病,且目前尚无治疗的特效药。我国人口基数大,现存感染者多,因此乙肝疫苗的预防接种在该病的预防控制中就显得尤为重要。但是,部分接种者在按照推荐的乙肝疫苗免疫程序接种后,并不能产生有效的保护性免疫应答。本综述旨在从机体、疫苗两个方面分析接种乙肝疫苗后无/低免疫应答的影响因素,探讨无/低免疫应答机制,从而对我国乙肝的防治提供科学依据。Hepatitis B virus(HBV)can cause a variety of hepatitis B-related diseases in infected people,and there is no specific drug for treatment.China,with a large population base,is the country with the heaviest burden of HBV infection in the world.Therefore,hepatitis B vaccination is particularly important in the prevention and control of this disease.However,some vaccinees did not produce effective protective immune response after vaccination according to the recommended hepatitis B vaccine immunization schedule.The purpose of this review is to analyze the influential factors of non/low immune response after hepatitis B vaccination from the aspects of organism and vaccine,and explore the mechanism of non/low immune response,so as to provide scientific basis for the prevention and treatment of hepatitis B in China.

关 键 词：乙肝疫苗 无/低应答 影响因素 

分 类 号：R186[医药卫生—流行病学]