辐射接枝磺酸基改性聚醚砜膜的研究  

Modification of polyethersulfone membrane by radiation grafting sulfonic acid

作　　者：蒋邵平 王果玉 彭朝荣[2,3] 赵伟锋 王静霞 赵长生 Jiang Shaoping;Wang Guoyu;Peng Chaorong;Zhao Weifeng;Wang Jingxia;Zhao Changsheng(College of Polymer Science and Engineering,Sichuan University,Chengdu 610065;Sichuan Atomic Energy Research Institute,Chengdu 610101;Irradiation Preservation Key Laboratory of Sichuan Province,Chengdu 610101)

机构地区：[1]四川大学高分子科学与工程学院,成都610065 [2]四川省原子能研究院,成都610101 [3]辐照保藏四川省重点实验室,成都610101

出　　处：《化工新型材料》2021年第11期79-84,共6页New Chemical Materials

基　　金：四川省科技支撑项目(2019YFS0134、2019YFH0180、2019JDRC0137、2019YJ0548)。

摘　　要：针对临床血液透析材料聚醚砜(PES)进行改性,利用伽马射线在PES膜表面引发辐射接枝聚合反应,接枝亲水性对苯乙烯磺酸钠(SSS),改善PES膜的亲水性和血液相容性。并进一步在其表面引入具有抗菌性的碘和纳米银,赋予膜材料抗菌性。采用红外光谱、水接触角、场发射扫描电镜和Zeta电位等方法表征改性的PES膜;同时优选接枝改性工艺,确定最优辐照工艺条件为0.3g/mL的SSS浓度和15kGy的辐照剂量。最后,通过血液相容性实验和抗菌实验表明,改性PES膜材料具有良好的血液相容性和抗菌性能。In order to improve the hemocompatibility and antibacterial activity of polyethersulfone(PES)membranes,radiation grafting polymerization was used to graft hydrophilic sodiump-styrene sulfonate(SSS)on the surfaces of the membranes.Then,iodine and silver nanoparticles as antibacterial agents were introduced to the modified PES membranes to endow the materials with antibacterial property.The modified PES membranes were characterized by FT-IR,water contact angle,SEM and Zeta potential.The results showed that the 0.3 g·mL-1 SSS concentration and the radiation dose of 15 kGy were the optimum reaction conditions.Hemocompatibility and antibacterial tests indicated that the modified PES membranes had excellent hemocompatibility and antibacterial property.

关 键 词：聚醚砜 辐射接枝聚合 血液净化 抗菌性 血液相容性 

分 类 号：R318.08[医药卫生—生物医学工程] TQ317[医药卫生—基础医学]