竹红菌素纳米纤维膜的制备及其光敏抗菌性能研究  

Preparation and photodynamic antibacterial property of hypocrellin nanofibrous membrane

作　　者：王婷婷[1] 曹秀明[2] 魏取福[1] 王清清[1,2] Wang Tingting;Cao Xiuming;Wei Qufu;Wang Qingqing(Key Laboratory of Eco-Textiles(Jiangnan University),Ministry of Education,Wuxi 214122;Jiangsu Sunshine Co.,Ltd.,Wuxi 214400)

机构地区：[1]生态纺织教育部重点实验室(江南大学),无锡214122 [2]江苏阳光股份有限公司,无锡214400

出　　处：《化工新型材料》2021年第11期289-293,共5页New Chemical Materials

基　　金：国家自然科学基金青年基金项目(51603090);2018年江苏省政策引导类计划(国际科技合作)项目(BZ2018032)。

摘　　要：针对耐药型细菌感染等疾病问题,利用共价固定法将光敏剂竹红菌素负载于细菌纤维素/壳聚糖复合材料上,制备具有光动力抗菌功能的纳米纤维膜。借助扫描电子显微镜、X射线衍射仪、傅里叶变换红外光谱仪和热重分析仪等手段分析比较固载竹红菌素前后纤维膜的形貌、结晶度、化学结构和热稳定性,并研究固载竹红菌素前后纤维膜对金黄色葡萄球菌和大肠杆菌的抗菌能力。结果表明:固载竹红菌素后,结晶度和热稳定性略有降低;在暗室条件下,纤维膜对金黄色葡萄球菌和大肠杆菌均具有良好的抗菌效果,在光照条件下,竹红菌素与壳聚糖的协同抗菌作用,使纤维膜对金黄色葡萄球菌的抗菌率提至99.9999%。To meet the challenge of drug-resistant bacterial infection,the hypocrellin photosensitizer was covalently loaded on the bacterial cellulose/chitosan composite membrane to prepare the photodynamic antibacterial nanofiber membrane.The morphology,crystallinity,chemical structure and thermostability of the membrane before and after the addition of Hc were compared by scanning electron microscopy,X-ray diffraction,fourier transform infrared spectrometry and thermogravimetric analysis.The antibacterial ability to S.aureus and Ec.oli were also investigated to explore its photodynamic efficiency.The results shown that the addition of Hc slightly decreased their crystallinity and thermostability.The membrane shown good antibacterial effect against S.aureus and Ec.oli in the dark.Furthermore,the antibacterial effect against S.aureus reached 99.9999%under illumination due to the synergy of hypocrellin and chitosan.

关 键 词：竹红菌素 三聚氯氰 细菌纤维素 壳聚糖 光动力抗菌 

分 类 号：TQ342[化学工程—化纤工业] O614.4[理学—无机化学]