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作 者:朱伟堃 井改革 赵蕊蕊 王素香 赵丹彤[2] ZHU Wei-kun;JING Gai-ge;ZHAO Rui-rui;WANG Su-xiang;ZHAO Dan-tong(Heze Institute for Food and Drug Control,Heze 274000,China;College of Pharmacy,Shandong University of Traditional Chinese Medicine,Jinan 250355,China)
机构地区:[1]菏泽市食品药品检验检测研究院,山东菏泽274000 [2]山东中医药大学药学院,山东济南250355
出 处:《食品与药品》2021年第6期493-498,共6页Food and Drug
基 金:2020年山东省药品质量风险监测资助项目。
摘 要:目的建立同时测定清热解毒口服液中绿原酸、栀子苷、连翘苷、黄芩苷含量的方法,并综合评价其质量。方法采用高效液相色谱法(HPLC)同时测定清热解毒口服液中4种成分含量,并结合雷达图分析、聚类分析和主成分分析等多元统计分析,比较不同企业样品的总体质量。结果含量测定方法学考察结果均符合有关要求,雷达图分析、聚类分析和主成分分析均将样品分为2类。结论本研究所建立的HPLC法结合多元统计分析,能较好地反映各企业清热解毒口服液的整体质量。Objective To establish a method for simultaneous determination of chlorogenic acid, geniposide, phillyrin and baicalin in Qingre Jiedu Oral Liquid, and comprehensively evaluate its quality. Methods The contents of four components in Qingre Jiedu Oral Liquid were determined by HPLC. Combined with multiple statistical analysis such as radar image analysis(RIA), cluster analysis(CA) and principal component analysis(PCA), the overall qualities of samples from different enterprises were compared. Results The results of methodologic investigation met relevant requirements. The samples were classified in to two categories by RIA, CA and PCA. Conclusion The overall quality of Qingre Jiedu Oral Liquid could be well reflected by HPLC combined with multiple statistical analysis.
关 键 词:清热解毒口服液 含量测定 高效液相色谱 雷达图分析 聚类分析 主成分分析
分 类 号:R917[医药卫生—药物分析学]
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