糖肾安方对早期糖尿病肾病患者尿微量白蛋白及微炎症、胰岛素抵抗的影响  

Effects of Tangshenan Formula on Micro-Urinary Albumin,Microinflammation and Insulin Resistance in Patients with Early Diabetic Nephropathy

作　　者：郑宏香[1] 陈岱[1] 王身菊[1] 赵敏[1] 朱美凤[1] 万冰莹 ZHENG Hong-xiang;CHEN Dai;WANG Shen-ju;ZHAO Min;ZHU Mei-feng;WAN Bing-ying(Changzhou Hospital of Traditional Chinese Medicine, Changzhou, 213000, China)

机构地区：[1]常州市中医医院,江苏常州213000

出　　处：《南京中医药大学学报》2021年第6期860-864,共5页Journal of Nanjing University of Traditional Chinese Medicine

基　　金：全国名老中医药专家张志坚传承工作室(国中医药人教发〔2011〕3号);常州市陈岱名中医工作室(常卫中医〔2020〕275号)。

摘　　要：目的观察糖肾安方对早期糖尿病肾病(DN)患者尿微量白蛋白(micro-UALB)、微炎症状态、胰岛素抵抗(IR)的影响。方法86例早期DN气阴两虚兼血瘀证的患者,按照随机数字表法分为对照组与观察组各43例。对照组进行常规治疗,观察组在对照组的治疗基础上加服糖肾安方。12周后比较2组患者治疗前后的中医证候积分、尿蛋白指标[尿微量白蛋白(micro-UALB)、尿白蛋白/尿肌酐(UACR)]、血清炎症因子[白细胞介素6(IL-6)、C反应蛋白(CRP)、肿瘤坏死因子α(TNF-α)]、胰岛素抵抗指标[空腹胰岛素(FIN)、稳态模型评估IR指数(HOMA-IR)、空腹血糖(FBG)]及肾功能指标[血清肌酐(SCr)、血尿素(BUN)]的变化。结果治疗后,观察组中医证候积分、尿蛋白指标、炎症指标、IR指数均明显下降,差异具有统计学意义(P<0.05,P<0.01),观察组优于对照组(P<0.05,P<0.01)。结论糖肾安方可有效改善早期DN患者症状、减少尿蛋白、抑制炎症因子及改善胰岛素抵抗。OBJECTIVE To observe the effects of Tangshenan formula on micro-urinary albumin(micro-UALB),microinflammatory status and insulin resistance(IR)in patients with early diabetic nephropathy(DN).METHODS A total of 86 patients with early stage DN,identified as deficiency of both qi and yin combined with blood stasis syndrome,were divided into 43 patients in the control group and 43 patients in the observation group according to the random number table.The control group was treated conventionally,while the observation group was treated with Tangshenan formula on the basis of the treatment of the control group.After 12 weeks of treatment,we compared the changes in traditional Chinese medicine(TCM)syndrome score,urine protein indexes[urine micro-UALB,urine albumin/urinary albumin creatinine(UACR)],serum microinflammatory factors[interleukin 6(IL-6),C-reactive protein(CRP),tumor necrosis factorα(TNF-α)],insulin resistance indexes[fasting insulin(FIN),homeostasis model assessment IR index(HOMA-IR)],fasting blood glucose(FBG),as well as renal function indexes[serum creatinine(SCr),blood urea nitrogen(BUN)].RESULTS After treatment,the TCM syndrome score,urine protein index,inflammation index and IR index in the observation group reduced significantly,and the differences were statistically significant(P<0.05,P<0.01);the results in the treatment group were better than those in the control group(P<0.05,P<0.01).CONCLUSION Tangshenan formula can effectively relieve the symptoms,reduce proteinuria,inhibit inflammatory factors and enhance insulin resistance in early DN patients.

关 键 词：糖肾安方 早期糖尿病肾病 尿微量白蛋白 炎症因子 胰岛素抵抗 

分 类 号：R255.4[医药卫生—中医内科学]