彩色视觉模拟焦虑评估滑动尺对CINV风险预测效能研究  

Study on predictive efficiency of color visual analog anxiety evaluation sliding scales in risk of chemotherapy induced nausea and vomiting

作　　者：邓本敏 宋佶芳 杨鸿 伍青 施玉梅 王林娟 刘婷婷 DENG Benmin;SONG Jifang;YANG Hong;WU Qing;SHI Yumei;WANG Linjuan;LIU Tingting(Chongqing Key Laboratory of Translational Research for Tumor Metastasis and Individualized Treatment,Chongqing University Affiliated Tumor Hospital,Chongqing 400030,China;Department of Oncology,Army Characteristic Medical Center,Chongqing 400037,China;Department of Oncology,Second Affiliated Hospital of Army Military Medical University,Chongqing 400037,China)

机构地区：[1]重庆大学附属肿瘤医院肿瘤转移与个体化诊治转化研究重庆市重点实验室,400030 [2]陆军特色医学中心肿瘤科,重庆400042 [3]陆军军医大学第二附属医院肿瘤科,重庆400037

出　　处：《重庆医学》2021年第23期4033-4038,共6页Chongqing medicine

基　　金：重庆市科学技术局项目(cstc2019jscx-msxmX0247);重庆市科卫联合中医药科研项目(2019ZY023322)。

摘　　要：目的探讨彩色视觉模拟焦虑评估滑动尺(CVASS-A)对肿瘤患者化疗相关性恶心呕吐(CINV)的风险预测效能。方法选择广泛性焦虑量表(GAD-7)、视觉模拟焦虑评分(VAS-A)与项目组设计的CVASS-A调查1000例肿瘤患者化疗前的焦虑评分,前瞻性分析3种焦虑评估工具与CINV的相关性。根据焦虑严重程度及是否发生CINV进行分组,评价CVASS-A的区分效度;采用Spearman相关性分析评价CVASS-A校标效度,受试者工作特征(ROC)曲线分析评价CVASS-A的预测效能、灵敏度及特异度。结果本研究中CINV发生率为46.36%,焦虑为CINV的高危风险因素,CVASS-A与GAD-7、VAS-A、CINV呈正相关(r=0.509、0.774、0.582,P<0.01)。CVASS-A对CINV预测的ROC曲线下面积(AUC)为0.809、灵敏度为0.774、特异性为0.794。结论CVASS-A对化疗患者焦虑评估具有较好的区分效度、校标效度,能简便快捷筛查化疗患者的焦虑情绪,对CINV发生有较好的预测效能。Objective To explore the predictive efficiency of the Color Visual Analog Sliding Scales-Anxiety evaluation(CVASS-A)in the risk of chemotherapy-related nausea and vomiting(CINV)in the patients with tumor.Methods The anxiety scores in 1000 patients with tumor were investigated by selecting the Generalized Anxiety Disorder(GAD-7),Visual Analog Scales-Anxiety(VAS-A)and CVASS-A designed by the item group.The correlation between the three kinds of anxiety evaluation tools with CINV was prospectively analyzed.The patients were grouped according to the anxiety severity and whether CINV occurring.The discrimination validity of CVASS-A was evaluated.The Spearman correlation analysis was adopted to evaluate the calibration validity of CVASS-A.The receiver operating characteristic(ROC)curve was used to evaluate the prediction efficiency,sensitivity and specificity.Results The occurrence rate of CINV was 46.36%in this study.The anxiety was the high risk factor of CINV.CVASS-A was positively correlated with GAD-7,VAS-A and CINV(r=0.509,0.774,0.582,P<0.01).The area under the ROC curve(AUC)was 0.809.The sensitivity was 0.774.The specificity was 0.794.Conclusion CVASS-A has good distinguishing validity and calibration validity,can screen the anxiety emotion of the patients with chemotherapy easily and quickly,and has better predictive efficacy for CINV occurrence.

关 键 词：化疗相关性恶心呕吐 焦虑 焦虑评估 风险预测 

分 类 号：R730.53[医药卫生—肿瘤]