钆塞酸二钠增强MRI信号强度与肝细胞癌分化程度的相关性研究  

Correlation between Gd-EOB-DTPA enhanced MRI signal intensity and differentiation degree of hepatocellular carcinoma

作　　者：李瑞[1] 李涛[1] 何娟 朱里[1] LI Rui;LI Tao;HE Juan;ZHU Li(Department of Medical Imaging,Fourth Affiliated Hospital of Guangxi Medical University/Liuzhou Worker′s Hospital,Liuzhou,Guangxi 545005,China;Department of Pathology,First Affiliated Hospital of Guangxi Medical University,Nanning,Guangxi 530021,China)

机构地区：[1]广西医科大学第四附属医院/柳州市工人医院医学影像科,广西柳州545005 [2]广西医科大学第一附属医院病理科,南宁530021

出　　处：《重庆医学》2021年第23期4065-4070,共6页Chongqing medicine

基　　金：广西卫生健康委员会自筹课题(Z2016189)。

摘　　要：目的探讨钆塞酸二钠(Gd-EOB-DTPA)增强磁共振成像(MRI)信号强度与肝细胞癌(HCC)病理分化程度的相关性。方法选择经病理证实为HCC的患者56例(65个HCC病灶),所有患者均行甲胎蛋白(AFP)检测及肝脏MRI平扫、Gd-EOB-DTPA动态增强扫描,统计分析AFP阴阳性、病灶大小及肝胆期病灶信号特征与术后病理分化程度的关系。结果AFP阳性组高分化6个,中分化20个,低分化7个;AFP阴性组高分化10个,中分化11个,低分化11个。<1 cm病灶组,高分化1个,中分化5个,低分化0个;1~3 cm病灶组,高分化8个,中分化20个,低分化9个;>3 cm病灶组,高分化7个,中分化6个,低分化9个。AFP阴阳性、不同病灶大小组HCC分化程度比较,差异无统计学意义(P>0.05)。低信号组高分化0个,中分化14个,低分化8个;混杂信号组高分化5个,中分化15个,低分化10个;高信号组高分化11个,中分化2个,低分化0个。HCC病灶不同肝胆期信号强度组病理分化程度比较,差异有统计学意义(P<0.05)。结论Gd-EOB-DTPA增强MRI肝胆期信号强度与HCC病理分化程度明显相关,且信号强度越低HCC分化程度越低。Objective To investigate the correlation between gadolinium ethoxybenzyl diethylenetriamine-pentaacetic acid(Gd-EOB-DTPA)-enhanced magnetic resonance imaging(MRI)and the differentiation degree of hepatocellular carcinoma(HCC).Methods Fifty-six patients with pathologically cofirmed HCC(65 HCC lesions)were selected.All patients conducted alpha fetoprotein(AFP)detection,liver MRI plain scan and Gd-EOB-DTPA dynamic enhanced scan.The differences of AFP negative or positive,lesion size,signal characteristics of hepatobiliary lesions and pathological differentiation degree after operation were statistically analyzed.Results In the AFP positive group,there were 6 lesions of well differentiation,20 lesions of moderate differentiation and 7 lesions of poorly differentiation,and the AFP negative group had 10 lesions of well differentiation,11 lesions of moderate differentiation and 11 lesions of poor differentiation.In the lesion<1 cm group,there were 1 lesion of well differentiation,5 lesions of moderate differentiation and 0 lesion of poor differentiation.In the lesion 1-3 cm group,there were 8 lesions of well differentiation,20 lesions of moderate differentiation and 9 lesions of poor differentiation.In the lesion>3 cm group,there were 7 lesions of well differentiation,6 lesions of moderate differentiation and 9 lesions of poor differentiation.There was no statistically significant differences in the AFP negative or positive,focus size and differentiation degree of HCC(P>0.05).In the low signal group,there were 0 lesion of well differentiation,14 lesions of moderate differentiation and 8lesions of poor differentiation.In the clutter signal group,there were 5 lesions of well differentiation,15 lesions of moderate differentiation and 10 lesions of poor differentiation.In the high signal group,there were 11 lesions of well differentiation,2 lesions of moderate differentiation and 0 lesions of poor differentiation.There was statistically significant difference in the signal intensity of hepatobiliary stage and the pathologic

关 键 词：钆塞酸二钠 磁共振成像 肝细胞癌 分化程度 

分 类 号：R445.2[医药卫生—影像医学与核医学]