中药白芍现代研究进展及其质量标志物的预测分析  

Modern research progress of traditional Chinese medicine Paeoniae Radix Alba and prediction of its Q-markers

作　　者：徐佳新 许浚[2,3] 曹勇[4,5] 朱月健 李翔宇[4,5] 葛德助 马磊[4,5] 张铁军 刘昌孝 XU Jia-xin;XU Jun;CAO Yong;ZHU Yue-jian;LI Xiang-yu;GE De-zhu;MA Lei;ZHANG Tie-jun;LIU Chang-xiao(School of Chinese Materia Medica,Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China;Tianjin Key Laboratory of Quality Marker of Traditional Chinese Medicine,Tianjin Institute of Pharmaceutical Research,Tianjin 300301,China;State Key Laboratoty of Drug Delivery Technology and Pharmacokinetics,Tianjin Institute of Pharmaceutical Research,Tianjin 300301,China;Anhui Jiren Pharmaceutical Co.,Ltd.,Bozhou 236800,China;Anhui Innovation Center of Extraction Technology of Traditional Chinese Medicine,Bozhou 236800,China)

机构地区：[1]天津中医药大学中药学院,天津300193 [2]天津药物研究院天津市中药质量标志物重点实验室,天津300301 [3]天津药物研究院释药技术与药代动力学国家重点实验室,天津300301 [4]安徽济人药业有限公司,安徽亳州236800 [5]中药提取安徽省技术创新中心,安徽亳州236800

出　　处：《中国中药杂志》2021年第21期5486-5495,共10页China Journal of Chinese Materia Medica

基　　金：中医药国际合作专项(0610-2040NF020928);国家“重大新药创制”科技重大专项(2018ZX09721004-006);亳州市科技重大专项(BZSKXJSJ2020-59);中央引导地方科技发展专项(20ZYCGSN00200)。

摘　　要：白芍为毛茛科芍药属植物芍药的干燥根,始载于《神农本草经》,列为上品,是常见的补血药,其化学成分主要有单萜及其苷类、三萜类、黄酮类等。现代研究表明,白芍具有抗炎、镇痛、保肝、抗氧化等作用,被广泛应用于临床,具有广阔的开发前景。该文对白芍的化学成分、药理作用及质量控制方法的研究进展进行总结,并在此基础上结合质量标志物(Q-marker)的核心概念,从质量传递与溯源、化学成分特有性、化学成分有效性及化学成分可测性等方面对白芍的质量标志物进行预测分析,为白芍的质量评价研究提供科学依据。Paeoniae Radix Alba is the dried root of Paeonia lactiflora, which was first recorded in the Shennong′s Classic of Materia Medica and listed as the top grade. It is a common blood-tonifying herb, and its chemical components are mainly monoterpenes and their glycosides, triterpenes, flavonoids and so on. Modern research has demonstrated that Paeoniae Radix Alba has the activities of anti-inflammation, pain easing, liver protection, and anti-oxidation, and thus it is widely used in clinical practice and has broad development prospects. In this paper, the research progress on the chemical composition, pharmacological effects, and quality control of Paeoniae Radix Alba were summarized. On this basis, the Q-markers of Paeoniae Radix Alba were predicted from the aspects of mass transfer and traceability, chemical composition specificity, and availability and measurability of chemical components, which will provide a scientific basis for the quality evaluation of Paeoniae Radix Alba.

关 键 词：白芍 化学成分 药理作用 质量评价 质量标志物 

分 类 号：R284.1[医药卫生—中药学]