基于层次分析-熵权法和网络药理学的野马追质量标志物研究  

Research on Q-markers of Eupatorium lindleyanum based on analytic hierarchy process-entropy weight method and network pharmacology

作　　者：黄露 徐顶巧 乐世俊 陈艳琰 付瑞嘉 陆哲 唐于平 HUANG Lu;XU Ding-qiao;YUE Shi-jun;CHEN Yan-yan;FU Rui-jia;LU Zhe;TANG Yu-ping(Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for Traditional Chinese Medicine Compatibility,Shaanxi University of Chinese Medicine,Xi′an 712046,China)

机构地区：[1]陕西中医药大学陕西省中医药管理局中药配伍重点实验室,陕西西安712046

出　　处：《中国中药杂志》2021年第21期5545-5554,共10页China Journal of Chinese Materia Medica

基　　金：国家重点研发计划项目(2019YFC1711000);陕西省自然科学基金一般项目(青年)(2020JQ-862);陕西省教育厅专项项目(20JK0602)。

摘　　要：基于层次分析(analytic hierarchy process,AHP)-熵权法(entropy weight method,EWM)和网络药理学方法研究野马追潜在的质量标志物(Q-marker)。基于中药质量标志物的理念,应用层次分析-熵权法对野马追的质量标志物进行量化辨识,AHP法应用于一级指标有效性、可测性和特有性的权重分析,EWM法分析各项下有文献及实验数据支撑的二级指标。同时基于网络药理学的理论和方法,对野马追的"成分-靶点-疾病-功效"网络关系进行研究,筛选出与化痰止咳平喘功效关联性最强的成分。通过整合分析AHP-EWM法和网络药理学方法的筛选结果,综合确定芦丁、槲皮素、泽兰黄酮、线蓟素、木犀草素、金丝桃苷、异槲皮苷、山柰酚、咖啡酸、eupalinolide K、eupalinolide A、eupalinolide B、eupalinolide C共13个化合物作为野马追的潜在质量标志物。该研究基于质量标志物的理念,以野马追为研究对象,基于AHP-EWM法和网络药理学方法研究野马追的质量标志物,为野马追的质量控制提供参考依据。The potential quality markers( Q-markers) of Eupatorium lindleyanum were studied with analytic hierarchy process(AHP)-entropy weight method(EWM) and network pharmacological method. Based on the concept of Q-markers of traditional Chinese medicine, AHP-EWM was employed to quantitatively identify the Q-markers of E. lindleyanum. AHP method was applied to the weight analysis of the validity, testability, and specificity of the first-level indexes, and EWM method was used to analyze the secondlevel indexes supported by literature and experimental data. At the same time, based on the theory and method of network pharmacology, the component-target-disease-efficacy network of E. lindleyanum was built, and the components most closely related to the efficacy of resolving phlegm and relieving cough and asthma were screened out. Through the integrated analysis of the results obtained with AHP-EWM and network pharmacological method, 13 compounds including rutin, quercetin, nepetin, cirsiliol, luteolin, hyperoside,isoquercitrin, kaempferol, caffeic acid, eupalinolide K, eupalinolide A, eupalinolide B, and eupalinolide C were comprehensively identified as the potential Q-markers of E. lindleyanum. The results provide a basis for the quality control of E. lindleyanum.

关 键 词：野马追 质量标志物 层次分析-熵权法 网络药理学 

分 类 号：R285[医药卫生—中药学]