四维超声对前列腺运动靶体积分辨能力的研究  

Study of volume resolution of prostate motion target by four-dimensional ultrasound

作　　者：陆正大 毕卉 李春迎 和睦 高留刚 孙佳伟 谢凯 林涛 眭建锋 倪昕晔 Lu Zhengda;Bi Hui;Li Chunying;He Mu;Gao Liugang;Sun Jiawei;Xie Kai;Lin Tao;Sui Jianfeng;Ni Xinye(Academy of Biomedical Engineering and Information,Nanjing Medical University,Nanjing 210000,China;Department of Radiotherapy,Nanjing Medical University Affiliated Second People′s Hospital of Changzhou/Center for Medical Physics Nanjing Medical University/Key Laboratory of Medical Physics,Changzhou 213000,China)

机构地区：[1]南京医科大学生物医学工程与信息学院,210000 [2]南京医科大学附属常州第二人民医院放疗科/南京医科大学医学物理中心实验室/常州市医学物理重点实验室,213000

出　　处：《中华放射肿瘤学杂志》2021年第12期1292-1296,共5页Chinese Journal of Radiation Oncology

基　　金：江苏省卫健委面上项目(M2020006);常州市卫健委青年项目(QN201932);国家博士后67批面上项目(2020M671277)。

摘　　要：目的探究四维(4D)超声对运动靶体积分辨能力。方法选用前列腺超声模型,分组对比研究应用4D超声在不同运动振幅(A)及运动周期(T)下勾画前列腺靶区,模拟A值分别设置为0.5、1.0、2.0、3.0、4.0、5.0 mm,t值设为1、2、3、4 s。分别计算模体前列腺靶体积,并以靶区静止时超声图像作为对照,分析两者间差异。结果模体静止时超声靶体积与CT靶体积大小有较高一致性(P>0.05)。A值为0.5、1.0 mm,t值为1~4 s时的体积与静止时超声靶体积相近(均P>0.05);A值为2.0、3.0 mm,t值为1~3 s时靶体积与静止时超声靶体积不同(均P<0.05)。A值为2.0 mm,t值为4 s时靶体积与静止时超声靶体积相近(P=0.710),组内极差为6.7 cm^(3),标准差为1.15 cm^(3);A值为3.0 mm,t值为4.0 s时靶体积重复性差,组内极差为14.4 cm^(3);A值为4.0、5.0 mm,t值为1~4 s时组内极差分别为3.27~17.63 cm^(3)、6.51~21.02 cm^(3)。各周期下靶体积重复性很差,不能满足临床要求。结论4D维超声可在患者运动周期1~4 s内、运动幅度≤1 mm内为患者靶区勾画提供可靠参考数据,探头初始位置无影响。Objective To explore the volume resolution of prostate motion target by four-dimensional(4D)ultrasound.Methods The prostate ultrasound model was selected,and the group comparison study was conducted using 4D ultrasound to outline the prostate target under different motion amplitudes(A)and motion period(T).The simulated A value was set as 0.5 mm,1 mm,2 mm,3 mm,4 mm,and 5 mm,respectively.The T value was set as 1 s,2 s,3 s,and 4 s,respectively.The volume of the target of the model prostate was calculated,and the static ultrasound image of the target was used as the control group to analyze the difference between two groups.Results When the model was still,the size of the target of ultrasound was consistent with that of CT scan(P>0.05).When the A values were 0.5 mm and 1 mm,there was no statistical difference between the volume in period 1-4 s and the volume in the target at rest(all P>0.05).When the A values were 2 mm and 3 mm,and the T values were 1 s,2 s and 3 s there was statistical difference between the volume of target and that of of static ultrasonic target(all P<0.05).When the A value was 2 mm and the T value was 4 s,there was no statistical difference between the target volume and the static target volume(P=0.710).The range within the group was 6.7 cm^(3),and the standard deviation was 1.15 cm^(3).When the A value was 3 mm and the T value was 4 s,the volume repeatability of the target was poor,and the range within the group was 14.4 cm^(3);when the A values were 4 mm and 5 mm,and the T values were 1-4 s,the range within the group was 3.27-17.63 cm^(3) and 6.51-21.02 cm^(3),respectively.The volume repeatability of the target under each period was extremely poor,which could not meet the clinical requirements.Conclusion 4D ultrasound can provide reliable reference data for patients′target delineation within 1-4 s of motion cycle and within 1 mm of motion amplitude,which exerts on effect upon the original position of probe.

关 键 词：四维超声 运动幅度 运动周期 靶体积 前列腺模型 

分 类 号：R445.1[医药卫生—影像医学与核医学] R737.25[医药卫生—诊断学]