经腰大池灌洗置换炎性脑脊液在治疗颅脑术后严重颅内感染的标准化应用效果观察  

Standardized Application Effect of Replacing Inflammatory Cerebrospinal Fluid in the Treatment of Severe Intracranial Infection after Craniocerebral

作　　者：蔡龙杰 姜之全[1] 邵东奇 CAI Long-jie;JIANG Zhi-quan;SHAO Dong-qi(Department of Neurosurgery,the First Affiliated Hospital of Bengbu Medical College)

机构地区：[1]蚌埠医学院第一附属医院

出　　处：《中国标准化》2021年第22期210-213,共4页China Standardization

摘　　要：目的:观察经腰大池引流灌洗置换炎性脑脊液的方法对于治疗颅脑术后严重颅内感染的应用效果,为临床治疗提供参考依据。方法:选取蚌埠医学院第一附属医院自2020年1月至2021年6月收治的86例颅脑术后出现严重颅内感染患者为研究对象。将患者随机分入对照组和实验组,每组各43例。对照组只接受腰大池引流加阿米卡星鞘注。实验组接受腰大池引流联合灌洗炎性脑脊液置换加阿米卡星鞘注。比较两组患者治疗有效率、体温恢复时间和脑脊液生化、常规恢复时间。结果:对照组有效率为86%,实验组有效率为100%,差异有统计学意义(P<0.05)。实验组患者的体温恢复时间(中位数)为9.00(5.00-13.00)天,短于对照组的11.00(7.75-14.25)天,差异具有统计学意义(P<0.05)。实验组患者脑脊液白细胞计数,蛋白质及葡萄糖指标恢复正常所经历时间(中位数)为10.00(8.00-14.00)天,短于对照组的18.50(13.75-22.25)天,差异具有统计学意义(P<0.01)。结论:经腰大池引流灌洗置换炎性脑脊液的方法可以更快速有效地控制颅脑术后严重颅内感染,具有临床推广价值。Objective:To explore the effect of inflammatory cerebrospinal fluid replacement through lumbar puncture on treatment of patients with severe intracranial infections so as to provide guidance for clinical treatment.Methods:86 patients with severe postoperative intracranial infections admitted to the First Affiliated Hospital of Bengbu Medical College from January 2020 to June 2021 were selected and randomly divided into control group and experimental group,with 43 cases in each.The control group was treated with continuous lumbar drainage combined with intrathecal injection of amikacin,while the experimental group was given additional inflammatory cerebrospinal fluid replacement through lumbar drainage.The effective rate,the recovery time for body temperature and parameters of cerebrospinal fluid examination were observed and compared between the two groups of patients.Results:The effective rate in control group was 86%.While the effective rate in the experimental group was 100%,which was significantly higher than the control group(P<0.05).The median(interquartile range)recovery time for body temperature in the experimental group was significantly shorter than that in the control group[9.00(5.00-13.00)d and 11.00(7.75-14.25)d respectively](P<0.05).The median(interquartile range)recovery time for parameters of cerebrospinal fluid examination in the experimental groupwas also significantly shorter than that in the control group[10.00(8.00-14.00)d and 18.50(13.75-22.25)d,respectively](P<0.01).Conclusion:Infl ammatory cerebrospinal fl uid replacement through lumbar puncture can cure moderate to severe intracranial infections more rapidly and effectively,and it is worthy to be promoted in the hospital.

关 键 词：颅脑术后严重颅内感染 腰大池引流 灌洗置换炎性脑脊液 标准化应用 

分 类 号：R651.1[医药卫生—外科学]