The genomes of Taxus species unveil novel candidates in the biosynthesis of taxoids  

作　　者：Youjun Zhang Federico Scossa Alisdair R.Fernie 

机构地区：[1]Center of Plant Systems Biology and Biotechnology,4000 Plovdiv,Bulgaria [2]Max-Planck-lnstitut fur Molekulare Pflanzenphysiologie,Am Muhlenberg 1,14476 Potsdam-Golm,Germany [3]Research Center for Genomics and Bioinformatics(CREA-GB),Via Ardeatina 546,00178 Rome,Italy

出　　处：《Molecular Plant》2021年第11期1773-1775,共3页分子植物（英文版）

基　　金：A.R.F.and Y.Z.thank the European Union's Horizon 2020 research and innovation program,project Planta SYST(SGA-CSA no.739582 under FPA no.664620)for supporting their research.

摘　　要：Taxaceae is the yew family of conifers and includes evergreen trees and small shrubs mainly distributed in Eurasia and North America.The genus of Taxus has attracted considerable attention since Monroe E.Wall and Mansukh C.Wani firstly isolated and characterized an unusual cyclic diterpenoid from the bark of the Pacific yew tree(Wani et al.,1971).This compound,subsequently called paclitaxel,was shown to promote tubulin assembly into microtubules,preventing their disassembly.Subsequently,paclitaxel was approved for medical use against ovarian cancer in 1992(Fischer and Ganellin,2010).

关 键 词：UNUSUAL Monro COMPOUND 

分 类 号：Q943[生物学—植物学]