大剂量呋塞米持续静脉泵入治疗重度心力衰竭患者的临床疗效  

Clinical Efficacy of Continuous Intravenous Pumping of High-dose Furosemide in the Treatment of Patients with Severe Heart Failure

作　　者：胡浩阳 HU Hao-Yang(Department of Cardiology,Shenyang 739 Hospital,Shenyang 110034,China)

机构地区：[1]沈阳七三九医院心血管内科,沈阳110034

出　　处：《中国药物经济学》2021年第11期113-115,119,共4页China Journal of Pharmaceutical Economics

摘　　要：目的探讨持续静脉泵入大剂量呋塞米治疗重度心力衰竭患者的临床效果。方法选取沈阳七三九医院2019年1月至2020年1月收治的70例重度心力衰竭患者作为研究对象,采用随机数字表法分为观察组和对照组,各35例。对照组采用常规静脉推注呋塞米治疗,观察组采用大剂量呋塞米持续静脉泵入治疗,比较两组患者治疗前后心输出量、左室射血分数心功能指标水平,水肿、气促、呼吸困难等症状消退时间,住院时间,治疗过程中低血压、低血钾发生率。结果治疗前,两组心输出量、左室射血分数比较差异无统计学意义(P>0.05);治疗后,观察组患者心输出量(71.07±3.25)ml、左室射血分数(52.67±4.84)%显著高于对照组(58.68±2.44)ml、(39.52±3.16)%,观察组水肿消退时间(3.25±0.25)d、气促消退时间(3.21±0.24)d、呼吸困难消退时间(3.07±0.35)d、住院时间(4.36±0.27)d显著短于对照组(6.78±0.44)d、(5.37±0.68)d、(5.92±0.71)d、(8.39±0.74)d,观察组治疗过程中低血压发生率(2.86%)、低血钾发生率(2.86%)显著低于对照组(17.14%)、(14.29%),差异有统计学意义(P<0.05)。结论持续静脉泵入大剂量呋塞米治疗重度心力衰竭的临床效果显著。Objective To explore the clinical effect of continuous intravenous pumping of high-dose furosemide in the treatment of patients with severe heart failure.Methods A total of 70 patients with severe heart failure admitted to Shenyang 739 Hospital from January 2019 to January 2020 were selected as the research objects,and were divided into a study group and a control group by a random number table method,with 35 cases in each group.The control group used conventional intravenous bolus of furosemide treatment,the study group used high-dose furosemide continuous intravenous pump treatment.The cardiac output,left ventricular ejection fraction,cardiac function index levels,subsiding time of edema,shortness of breath,dyspnea and other symptoms,the length of hospital stay,and the incidence of hypotension and hypokalemia during treatment were compared between the 2 groups before and after treatment.Results Before treatment,there was no statistically significant difference between the 2 groups of patients in cardiac output,left ventricular ejection fraction(P>0.05).After treatment,the study group’s cardiac output was(71.07 ± 3.25) ml,ventricular ejection fraction(52.67 ± 4.84)% were significantly higher than those in the control group(58.68±2.44) ml,(39.52±3.16)%.And the time to subside edema in the study group was(3.25±0.25) d and the time to subside shortness of breath was(3.21±0.24) d,the time to subside dyspnea was(3.07±0.35) d,and the hospitalization time was(4.36±0.27) d,which were significantly shorter than those of the control group(6.78±0.44) d,(5.37±0.68) d,(5.92±0.71) d,(8.39±0.74) d.The incidence of hypotension(2.86%) and hypokalemia(2.86%)during treatment in the study group were significantly lower than those in the control group(17.14%),(14.29%),the comparison between the 2 groups was statistically significant(P<0.05).Conclusion Continuous intravenous pumping of high-dose furosemide has a significant clinical effect in the treatment of severe heart failure.

关 键 词：大剂量 呋塞米 持续静脉泵入 重度 心力衰竭 

分 类 号：R541.6[医药卫生—心血管疾病] R972[医药卫生—内科学]