GLP-1R基因多态性与2型糖尿病患者利拉鲁肽疗效的相关性研究  

The relationship between GLP-1R gene polymorphism and the efficacy of liraglutide in patients with type 2 diabetes

作　　者：王飞羽[1] 江震[2] 刘亦伟[1] WANG Feiyu;JIANG Zhen;LIU Yiwei(Department of Pharmacy,the First Affiliated Hospital of Fujian Medical University,Fuzhou 350005,China;Department of Endocrinology,the First Affiliated Hospital of Fujian Medical University,Fuzhou 350005,China)

机构地区：[1]福建医科大学附属第一医院药学部,福州350005 [2]福建医科大学附属第一医院内分泌科,福州350005

出　　处：《上海医药》2021年第23期21-24,共4页Shanghai Medical & Pharmaceutical Journal

基　　金：福建省中青年教师教育科研项目(JT180186);福建医科大学启航基金项目(2018QH1071)。

摘　　要：目的:探讨2型糖尿病(T2DM)患者胰高血糖素样肽-1受体(GLP-1R)基因单核苷酸多态性与利拉鲁肽疗效的关联性。方法:入选的T2DM患者给予利拉鲁肽12周,测定治疗前后糖化血红蛋白(HbA1c)水平。同时对其GLP-1R基因单核苷酸多态性(rs6923761、rs10305420、rs3765467、rs2254336)进行检测,统计分析降糖疗效与基因多态性的相关性。结果:最终纳入的62例患者,与野生型相比,HbA1c值在s3765467纯突变型(AA)患者中下降更显著(P<0.05),但在其余各基因型患者间无显著差异。结论:rs3765467基因多态性可能影响利拉鲁肽的降糖疗效,未发现rs6923761、rs10305420、rs2254336基因多态性对利拉鲁肽降糖疗效的影响。Objective:To explore the association between the single nucleotide polymorphisms(SNPs) on a glucagonlike peptide-1 receptor(GLP-1 R) gene and the efficacy of liraglutide in patients with type 2 diabetes(T2 DM).Methods:The T2 DM patients were treated with liraglutide for 12 weeks and glycosylated hemoglobin(HbA1 c) levels were determined before and after administration,also GLP-1 R(rs6923761,rs10305420,rs3765467,rs2254336) genotypes were measured.The relationship between the hypoglycemic effect and the gene polymorphism was analyzed.Results:Sixty-two patients were finally enrolled and the HbA1 c levels in the patients with rs3765467 pure mutant(AA) decreased more significantly compared with the wild type(P<0.05).There were no significant differences among the patients with other genotypes.Conclusion:The rs3765467 gene polymorphism may affect the hypoglycemic effect of liraglutide,and no effect of rs6923761,rs10305420,rs2254336 gene polymorphism on the hypoglycemic efficacy of liraglutide has been found.

关 键 词：2型糖尿病 利拉鲁肽 基因多态性 降糖疗效 

分 类 号：R977.15[医药卫生—药品] R587.1[医药卫生—药学]