2型糖尿病合并隐蔽性高血压患者动脉硬化程度的相关因素分析  

Relevant factor analysis of arteriosclerosis in T2DM patients with masked hypertension

作　　者：王思雯 张珺 张璐 王敏 张红梅 WANG Siwen;ZHANG Jun;ZHANG Lu;WANG Min;ZHANG Hongmei(Department of Geriatrics, Xining First People's Hospital, Xining 810000, China;Department of Cardiovascular medicine, Xining First People's Hospital, Xining 810000, China)

机构地区：[1]西宁市第一人民医院老年病科,青海西宁810000 [2]西宁市第一人民医院心血管内科,青海西宁810000

出　　处：《西部医学》2021年第12期1854-1857,共4页Medical Journal of West China

基　　金：青海省医药卫生科技项目(2018-wjzdx-138)。

摘　　要：目的探讨血清内皮素-1(ET-1)、同型半胱氨酸(Hcy)、超敏C-反应蛋白(hs-CRP)、白介素-6(IL-6)与2型糖尿病(T2DM)伴隐蔽性高血压(MHT)患者动脉硬化(AS)程度的相关性。方法选取2019年2月~2020年5月我院收治的T2DM患者129例,就诊时血压<140/90 mmHg,根据24 h动态血压监测分为NH组(n=76)和MHT组(n=53)。采用酶联免疫分析法对两组患者空腹时血清ET-1、Hcy、hs-CRP和IL-6含量进行测定,并进行臂踝动脉baPWV、血管舒张功能(FMD)及动脉内膜中层厚度(IMT)测定。分析血清ET-1、Hcy、hs-CRP和IL-6与baPWV、FMD及IMT的相关性。结果与NH组比较,MHT组ET-1、Hcy、hs-CRP、IL-6、baPWV、IMT水平均明显升高(均P<0.05),FMD明显下降(P<0.05)。血清ET-1、Hcy、hs-CRP及IL-6水平与baPWV、IMT正相关,与FMD呈负相关(P<0.05)。高ET-1、Hcy、hs-CRP、IL-6及TC水平是T2DM伴MHT患者动脉硬化程度的重要危险因素(P<0.05)。结论T2DM合并MHT患者动脉硬化程度的增加与炎性因子水平及内皮功能受损相关。Objective To investigate the correlation between serum endotherin-1(ET-1),homocysteine(Hcy),hypersensitive C-reactive protein(HS-CRP)and interleukin-6(IL-6)and the degree of AS in patients with T2DM with masked hypertenion.Methods 29 patients with T2DM treated in our hospital from February 2019 to may 2020 were selected.Their blood pressure was less than 140/90 mmHg.They were divided into NH group(n=76)and MHT group(n=53)according to 24-h ambulatory blood pressure monitoring.The contents of serum ET-1,Hcy,hs CRP and IL-6 were measured by enzyme-linked immunosorbent assay,and the brachial ankle artery baPWV,vasodilation function(FMD)and arterial intima-media thickness(IMT)were measured.The correlation between serum ET-1,Hcy,hs CRP and IL-6 and baPWV,FMD and IMT was analyzed.Results Compared with NH group,the levels of ET-1,Hcy,hs-CRP,IL-6,baPWV and IMT in MHT group increased significantly(P<0.05),and FMD decreased significantly(P<0.05).The levels of serum ET-1,Hcy,hs-CRP and IL-6 were positively correlated with baPWV and IMT,and negatively correlated with FMD(P<0.05).High levels of ET-1,Hcy,hs-CRP,IL-6 and TC were important risk factors for the degree of arteriosclerosis in T2DM patients with MHT(P<0.05).Conclusion The degree of atherosclerosis with T2DM combined with MHT is associated with inflammatory factors and impaired endothelial function.

关 键 词：2型糖尿病 隐蔽性高血压 动脉硬化 

分 类 号：R541.3[医药卫生—心血管疾病] R587.1[医药卫生—内科学]