载有ε-聚赖氨酸的纳米纤维膜的制备及其抗菌性能评价  

Preparation and antibacterial evaluation of nanofiber membrane loaded with ε-polylysine

作　　者：唐志敏 李彦 王璐[1,2] TANG Zhimin;LI Yan;WANG Lu(College of Textiles,Ministry of Education,Donghua University,Shanghai 201620,China;Key Laboratory of Textile Science&Technology,Ministry of Education,Donghua University,Shanghai 201620,China)

机构地区：[1]东华大学纺织学院,上海201620 [2]东华大学纺织面料技术教育部重点实验室,上海201620

出　　处：《东华大学学报（自然科学版）》2021年第6期22-28,共7页Journal of Donghua University(Natural Science)

摘　　要：开发可应对耐药菌感染的创面敷料成为医用纺织领域的研究重点之一。采用静电纺丝技术,将聚乙烯醇(PVA)和海藻酸钠(SA)按不同质量比共混纺丝,随SA质量分数的增加,混纺纤维膜力学性能呈下降趋势。优选力学性能较好的混纺纤维膜涂覆ε-聚赖氨酸(ε-PL),因混纺膜中具有水溶性的PVA遇水溶解可释放出抗菌药物ε-PL,且PVA可与SA交联产生缓释效应。通过扫描电子显微镜、强力仪、红外光谱仪及抗菌试验对混纺膜的微观形貌、力学性能、表面化学成分及抗菌性能等进行表征。结果表明,ε-PL被成功负载于混纺纤维膜中,混纺膜耐水溶性大幅提高,并且对耐药金黄色葡萄球菌和铜绿假单胞菌有一定的抑制作用。The development of wound dressings that can deal with drug-resistant bacteria infection has become one of the most important research focuses in medical textile field. Polyvinyl alcohol(PVA) and sodium alginate(SA) are blended and spun at different mass ratios using electrospinning technology. As the mass fraction of SA increases, the mechanical properties of the blended fiber membranes show a downward trend. The blended fiber membranes with better mechanical properties were coated with ε-polylysine(ε-PL). Because when the water-soluble PVA in the blended membrane dissolves in the water, it can release the antibacterial drug ε-PL and be cross-linked with SA to produce sustained release effect. The microscopic morphology, mechanical property, surface composition and antibacterial property of the blended membranes were characterized by scanning electron microscope, force meter, infrared spectroscopy and antibacterial tests. The results show that ε-PL is successfully loaded in the blended fiber membranes, the water solubility of blended membrane is greatly improved, and it has a certain inhibitory effect on drug-resistant Staphylococcus aureus and Pseudomonas aeruginosa.

关 键 词：纳米纤维膜 抗菌性能 药物缓释 聚乙烯醇 海藻酸钠 

分 类 号：TS101.4[轻工技术与工程—纺织工程]