大剂量激素联合高压氧治疗DEACMP的临床效果  

Clinical effect of high-dose hormone combined with hyperbaric oxygen in the treatment of DEACMP

作　　者：徐丹 宋大庆[2] XU Dan;SONG Da-qing(Emergency Medicine Major,Clinical School of Shandong Jining Medical College,Jining Shandong Province 272000,China;Jining First People’s Hospital)

机构地区：[1]山东济宁医学院临床医学院急诊医学专业,山东济宁272000 [2]济宁市第一人民医院

出　　处：《中国城乡企业卫生》2021年第11期133-135,共3页Chinese Journal of Urban and Rural Enterprise Hygiene

摘　　要：目的分析急性一氧化碳中毒迟发性脑病(DEACMP)患者应用大剂量激素联合高压氧治疗的效果。方法选取2018年6月—2020年3月济宁市第一人民医院收治的70例DEACMP患者为观察对象,根据随机数字表法分为对照组和研究组各35例。对照组实施单一高压氧治疗,研究组实施大剂量甲强龙治疗1周后,改为强的松联合高压氧治疗。比较两组的临床疗效和治疗前后的日常生活能力、认知功能评分。结果研究组的临床总有效率为91.43%,明显高于对照组的71.43%,差异有统计学意义(P<0.05)。治疗后,两组的ADL和MMSE评分均高于治疗前,且研究组的ADL和MMSE评分高于对照组,差异均有统计学意义(P<0.05)。结论在DEACMP患者中实施大剂量激素联合高压氧治疗,能进一步改善其日常生活能力和认知功能,并提高临床治疗效果,值得临床推广应用。Objective To analyze the effect of high-dose hormone therapy combined with hyperbaric oxygen in patients with delayed encephalopathy after acute carbon monoxide poisoning(DEACMP).Methods From June 2018 to March 2020,70 patients with DEACMP admitted to Jining First People’s Hospital were selected as observation subjects,and they were divided into control group and study group with 35 cases in each group according to the random number table method.The control group was treated with single hyperbaric oxygen,and the study group was treated with prednisone combined with hyperbaric oxygen after one week of high-dose methylprednisolone.The clinical efficacy,activities of daily living and cognitive function scores before and after treatment were compared between the two groups.Results The total clinical effective rate of the study group was 91.43%,which was significantly higher than 71.43%of the control group,and the difference was statistically significant(P<0.05).After treatment,the ADL and MMSE scores of the two groups were higher than those before treatment,and the ADL and MMSE scores of the study group were higher than those of the control group,and the differences were statistically significant(P<0.05).Conclusion High-dose hormone combined with hyperbaric oxygen in the treatment of patientswith DEACMP could further improve their daily life ability and cognitive function,and improve the clinical treatment effect,which was worthy of clinical promotion and application.

关 键 词：急性一氧化碳中毒迟发性脑病 大剂量激素 高压氧 

分 类 号：R595.1[医药卫生—内科学]