中枢神经特异蛋白S-100β在慢性硬膜下血肿术后的临床意义  

Clinical significance of central nervous specific protein(S-100β)in patients with chronic subdural hematoma after operation

作　　者：谭宝东 崔连旭[1] 陆大鸿 彭四维 李昊旻 TAN Baodong;CUI Lianxu;LU Dahong(The Second Department of Neurosurgery,the First People's Hospital of Foshan,Foshan(528000),Guangdong China)

机构地区：[1]佛山市第一人民医院神经外二科,广东佛山528000

出　　处：《癫痫与神经电生理学杂志》2021年第6期338-342,共5页Journal of Epileptology and Electroneurophysiology(China)

基　　金：佛山市卫生健康局医学科研项目(NO:20200305)。

摘　　要：目的探究慢性硬膜下血肿(CSDH)钻孔引流术前后的中枢神经特异蛋白S-100β水平及其临床意义。方法选取2015年1月至2020年10月佛山市第一人民医院收治并行钻孔引流术的CSDH患者102例,入院时根据格拉斯哥昏迷量表(GCS)评分将患者分为轻度脑损伤组(13~15分),中度脑损伤组(9~12分)及重度脑损伤组(<9分)。采用酶联免疫吸附法检测患者在行钻孔引流术的术前和术后血清S-100β蛋白水平变化,分析不同脑损伤组血清S-100β蛋白水平变化,并分析其对术后复发的指导意义。结果与轻度脑损伤患者比较,中度脑损伤患者血清S-100β蛋白水平明显增高(P<0.05),重度脑损伤患者显著增高(P<0.01);CSDH患者术后7d的血清S-100β蛋白水平明显低于术前(P<0.05);术后复发组患者血清S-100β蛋白水平明显高于术后未复发组(P<0.05)。结论CSDH患者的血清S-100β蛋白水平可反映其脑损伤程度,评估术后是否会复发,对于患者术后的神经功能受损或恢复程度有着重要的临床意义。Objective To investigate the level of central nervous specific protein(S-100β)before and after drilling and drainage for chronic subdural hematoma(CSDH)and its clinical significance.Methods 102 CSDH patients with burr-hole drainage in our hospital were enrolled and divided into the mild brain injury group(13-15 points),the moderate brain injury group(9-12 points)and the severe brain injury group(<9 points)according to GCS scores.The changes of serum S-100βprotein levels of different brain injury groups before and after drilling were detected and compared by enzym-linked immunosorbent assay.Postoperative recurrence was analyzed.Results Compared with the patients with mild brain injury,the level of S-100βof the moderate brain injury group was obviously higher(P<0.05).The level of S-100βof the severe brain injury group was significantly higher(P<0.01).The level of S-100βin CSDH patients 7 days after surgery was significantly lower than that before surgery(P<0.05).S-100βlevel in the group with postoperative recurrence was significantly higher than that in the group without postoperative recurrence(P<0.05).Conclusion S-100βcan reflect the degree of brain injury in patients with CSDH,and forecast the possible postoperative recurrence.It plays an important role to evaluate the postoperative neurological recovery of patients with CSDH.

关 键 词：中枢神经特异蛋白 S-100Β蛋白 慢性硬膜下血肿 脑损伤 钻孔引流术 

分 类 号：R651.15[医药卫生—外科学]